Alnylam Awarded Federal Grant to Develop RNAi Therapeutics for Pandemic Flu
Alnylam's flu program, partnered with Novartis, is focused on the development of RNAi therapeutics targeting sequences that are common to all flu genomes, including those of avian origin such as the H5N1 strain. Earlier this year, Alnylam scientists and academic collaborators demonstrated in vitro anti-viral activity toward a human clinical isolate of the H5N1 virus. These potent effects toward H5N1 were achieved with multiple siRNAs that also showed anti-viral activity toward other flu strains. The alliance's lead RNAi therapeutic candidate, ALN-FLU01, is comprised of two siRNAs that target distinct, highly conserved gene sequences of the flu genome.
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