Alnylam and Isis License Intellectual Property for MicroRNA Gene Involved in Hepatitis C Virus Infection
MiR-122 is specifically expressed and is highly abundant in the human liver. The study by Jopling et al. from the laboratory of Peter Sarnow, Ph.D. at Stanford University demonstrates that miR-122 interacts directly with a specific 5' noncoding sequence of the HCV genome leading to increased abundance of the viral mRNA. Antagonism of miR-122 function using an antisense oligonucleotide resulted in a dramatic decrease of viral RNA.
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