ProtAffin AG announces preclinical data in Multiple Sclerosis for MCP-1 decoy program

24-Oct-2011 - Austria

ProtAffin AG announced preclinical data on its MCP-1 decoy program in a model of multiple sclerosis at the ECTRIMS/ACTRIMS conference.

The Company presented a poster on its MCP-1 decoy program at the Immunomodulation session at the ECTRIMS/ACTRIMS conference, which is the 5th Joint Triennial Congress of the European and Americas Committees for Treatment and Research in Multiple Sclerosis. The Company presented in vivo efficacy data of the glycan-binding MCP-1 decoy protein PA508 in a model of experimental autoimmune encephalomyelitis (EAE), a gold-standard preclinical model of Multiple Sclerosis. PA508 showed a significant improvement in the clinical score over 28 days, as well as histology in the CNS, with PA508 showing a reduction in inflammatory infiltrates and preservation of myelin structures in the spinal cord and cerebellum.

Prof. Andreas Kungl, CSO of ProtAffin commented: “We are excited by these data which indicates that Multiple Sclerosis is an additional therapeutic opportunity for this second program at ProtAffin, in addition to previously published data of PA508 in murine models of myocardial infarction, restenosis and autoimmune uveitis. It furthermore underlines the ability to efficiently generate multiple product candidates from ProtAffin’s proprietary CellJammer® discovery technology. As we move our lead program, the IL-8 decoy PA401 into Phase 1 Q2 2012, we aim to establish the innovative therapeutic concept of biopharmaceuticals targeting glycans as a novel modality to optimally down-regulate proteins that bind glycans.”

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