BAC Extends Partnership with GE Healthcare to Launch Alpha-1 Antitrypsin Select

19-Feb-2010 - Netherlands

BAC BV has extended its collaboration with GE Healthcare with the addition of a new bioprocess affinity chromatography ligand to GE Healthcare’s range of custom designed media. The latest addition to the range is an affinity resin for the purification of alpha-1 antitrypsin (AAT) from blood plasma, recombinant cell culture or transgenic sources. The new resin has been developed as part of GE Healthcare’s Custom Designed Media (CDM) programme and provides a new solution for AAT purification in the biopharmaceutical industry.

AAT deficiency is a common genetic disorder thought to affect approximately 200,000 people in North America and Europe, although it is believed that 95% of patients remain undiagnosed. AAT is a protease inhibitor that protects body fluids and tissues from the body’s own protease enzymes, and a deficiency can lead to emphysema, COPD, or in some cases, liver damage. AAT deficiency can be treated by supplementing patients’ AAT levels. Plasma-derived AAT therapeutics on the market include Prolastin (Talecris), Aralast (Baxter) and Zemaira (CSL Behring), and there are a number of recombinant products in development. With the current AAT therapy market being significantly underserved by a shortage of AAT supply BAC hopes that its AAT affinity ligand, developed as part of BAC’s CaptureSelect® range, will provide manufacturers with a more streamlined and higher yielding purification option.

The provision of custom ligands is one of BAC’s core businesses, with the resulting ligands feeding into its rapidly growing bioprocess commercial supply business through collaborations with partners such as GE Healthcare.

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Topic World Chromatography

Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!

20+ products
10+ whitepaper
20+ brochures