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TRPV1




transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens]
Identifiers
Symbol(s) TRPV1; DKFZp434K0220; VR1
External IDs OMIM: 602076 MGI: 1341787 Homologene: 12920
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 7442 193034
Ensembl ENSG00000196689 ENSMUSG00000005952
Uniprot Q8NER1 Q3V318
Refseq NM_018727 (mRNA)
NP_061197 (protein)
NM_001001445 (mRNA)
NP_001001445 (protein)
Location Chr 17: 3.42 - 3.45 Mb Chr 11: 73.05 - 73.08 Mb
Pubmed search [1] [2]

The Transient receptor potential vanilloid 1 or TRPV1 can refer to the TPR cation channel receptor or the gene which encodes it in Homo sapiens.

TRPV1 is a nonselective ligand-gated cation channel that may be activated by a wide variety of exogenous and endogenous stimuli, including heat greater than 43°C, low pH, anandamide, N-arachidonoyl-dopamine, and capsaicin. TRPV1 receptors are found in the central nervous system and the peripheral nervous system and are involved in the transmission and modulation of pain, as well as the integration of diverse painful stimuli. [1].[2]

Additional recommended knowledge

Contents

Clinical significance

Novel TRPV1 antagonists have shown efficacy in reducing nociception from inflammatory and neuropathic pain models in rats. This provides evidence that TRPV1 is the capsaicin's sole receptor.[3] In humans, drugs acting at TRPV1 receptors could potentially be used to treat neuropathic pain associated with multiple sclerosis, chemotherapy, or amputation, as well as pain associated with the inflammatory response of damaged tissue, such as in osteoarthritis.

See also

References

  1. ^ Cui et al. TRPV1 Receptors in the CNS Play a Key Role in Broad-spectrum Analgesia of TRPV1 Antagonists. The Journal of Neuroscience 26(37), 9385-93 (2006) PMID 16971522
  2. ^ Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De Petrocellis L, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V (2007). "An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.". Proceedings of the national academy of sciences 99 (12): 8400-5. PMID 12060783.
  3. ^ Story GM, Crus-Orengo L (July-August 2007). "Feel the burn". American Scientist 95 (4): 326-333. ISSN 0003-0996.

Further reading

  • Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes.". Cell Calcium 33 (5-6): 533-40. PMID 12765698.
  • Geppetti P, Trevisani M (2004). "Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function.". Br. J. Pharmacol. 141 (8): 1313-20. doi:10.1038/sj.bjp.0705768. PMID 15051629.
  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427-50. doi:10.1124/pr.57.4.6. PMID 16382100.
  • Szallasi A, Cruz F, Geppetti P (2007). "TRPV1: a therapeutic target for novel analgesic drugs?". Trends in molecular medicine 12 (11): 545-54. doi:10.1016/j.molmed.2006.09.001. PMID 16996800.
  • Pingle SC, Matta JA, Ahern GP (2007). "Capsaicin receptor: TRPV1 a promiscuous TRP channel.". Handb Exp Pharmacol (179): 155-71. doi:10.1007/978-3-540-34891-7_9. PMID 17217056.
  • Liddle RA (2007). "The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis.". Biochim. Biophys. Acta 1772 (8): 869-78. doi:10.1016/j.bbadis.2007.02.012. PMID 17428642.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "TRPV1". A list of authors is available in Wikipedia.
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