My watch list  


Systematic (IUPAC) name
yl]disulfanyl-pent-3-enyl] 2-methylpropanoate
CAS number 3286-46-2
ATC code A11DA02
PubChem 71124
Chemical data
Formula C32H46N8O6S2 
Mol. mass 702.89 g/mol
SMILES search in eMolecules, PubChem
Synonyms Arcalion, bisibuthiamine, youvitan
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 5 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status
Routes Oral

Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B1). It is indicated for the treatment of asthenia.[1] Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats[2] and patients of schizophrenia[2] suggests that it is a nootropic.


Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.[3]


Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,[2] which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.


  1. ^ Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.". J Assoc Physicians India 51: 891–5. PMID 14710977.
  2. ^ a b c Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.". Prog Neuropsychopharmacol Biol Psychiatry 29 (6): 928–35. PMID 15951087.
  3. ^
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sulbutiamine". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE