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Fipexide



Fipexide
Systematic (IUPAC) name
1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-
2-(4-chlorophenoxy)ethanone
Identifiers
CAS number 34161-24-5
ATC code N06BX05
PubChem 3351
Chemical data
Formula C20H21ClN2O4 
Mol. mass 388.845 g/mol
Pharmacokinetic data
Bioavailability  ?
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Therapeutic considerations
Pregnancy cat.

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Legal status
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Fipexide is a piperazine derivative drug invented in Italy in 1983.[1]

Additional recommended knowledge

It was used as a nootropic drug in France and Italy, mainly for the treatment of senile dementia,[2] but is no longer in common use due to the occurrence of rare adverse drug reactions including fever[3] and hepatitis. Fipexide is similar in action to other nootropic drugs such as piracetam and is structurally similar to another more well-known nootropic, centrophenoxine.

References

  1. ^ Missale C, Pasinetti G, Govoni S, Spano PF, Trabucchi M. Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level. Bollettino Chimico Farmaceutico. 1983 Feb;122(2):79-85.
  2. ^ Bompani R, Scali G. Fipexide, an effective cognition activator in the elderly: a placebo-controlled, double-blind clinical trial. Current Medical Research and Opinion. 1986;10(2):99-106.
  3. ^ Guy C, Blay N, Rousset H, Fardeau V, Ollagnier M. Fever caused by fipexide. Evaluation of the national pharmacovigilance survey. Therapie. 1990 Sep-Oct;45(5):429-31.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fipexide". A list of authors is available in Wikipedia.
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