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Benfotiamine



Benfotiamine
Systematic (IUPAC) name
S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-
formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate
Identifiers
CAS number 22457-89-2
ATC code A11DA03
PubChem 3032771
Chemical data
Formula C19H23N4O6PS 
Mol. mass 466.449 g/mol
Synonyms S-benzoylthiamine-O-monophosphate
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Benfotiamine (rINN, also known as benfotiamine or benphothiamine) is an allithiamin, a naturally-occurring lipophilic form of thiamine. The primary use of this antioxidant is as an "anti-age" supplement. However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica.

Additional recommended knowledge

Benfotiamine has shown to be an effective intervention for the treatment of diabetic retinopathy, neuropathy, and nephropathy, possibly because Benfotiamine is a transketolase activator that directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Benfotiamine". A list of authors is available in Wikipedia.
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