Marburg multiple sclerosis
Marburg multiple sclerosis, also known as malignant, acute or fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are Neuromyelitis optica (NMO), Balo concentric sclerosis and Schilder's disease.
Additional recommended knowledge
It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI.
It is usually lethal, but recently it has been found to be responsive to Mitoxantrone and Alemtuzumab, and it has also been responsive to autologous stem cells transplantation.
- ^ Fontaine B (2001). "Borderline forms of multiple sclerosis" (in French). Rev. Neurol. (Paris) 157 (8-9 Pt 2): 929-34. PMID 11787357.
- ^ In vivo MRI diagnosis
- ^ Responsiveness to Mitoxantrone
- ^ Alemtuzumab and craniotomy for severe acute demyelinating illness 
- ^ Kimiskidis VK, Sakellari I, Tsimourtou V, et al (2007). "Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome". doi:10.1177/1352458507082604. PMID 17942513.
|Nervous system pathology, primarily CNS (G00-G47, 320-349)|
of the CNS
|Meningitis (Arachnoiditis) - Encephalitis - Myelitis - Encephalomyelitis (Acute disseminated) - Tropical spastic paraparesis|
primarily affecting the CNS
|Huntington's disease - Spinocerebellar ataxia (Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic paraplegia)|
Spinal muscular atrophy: Werdnig-Hoffman disease - Kugelberg-Welander disease - Fazio Londe syndrome -
MND (Amyotrophic lateral sclerosis (ALS), Progressive muscular atrophy (PMA), Progressive bulbar, Pseudobulbar, PLS)
|Parkinson's disease - Neuroleptic malignant syndrome - Postencephalitic parkinsonism - Pantothenate kinase-associated neurodegeneration - Progressive supranuclear palsy - Striatonigral degeneration - Dystonia (Spasmodic torticollis, Meige's syndrome, Blepharospasm) - Essential tremor - Myoclonus - Chorea (Choreoathetosis) - Restless legs syndrome - Stiff person syndrome|
|Other degenerative /|
|Alzheimer's disease - Pick's disease - Alpers' disease - Dementia with Lewy bodies - Leigh's disease - Multiple sclerosis - Devic's disease - Central pontine myelinolysis - Transverse myelitis|
|Seizure/epilepsy||Focal (Simple partial, Complex partial) - Generalised (Tonic-clonic, Absence, Atonic, Benign familial neonatal) - Lennox-Gastaut - West - Epilepsia partialis continua - Status epilepticus (Complex partial status epilepticus)|
|Headache||Migraine (Familial hemiplegic) - Cluster - Vascular - Tension|
|Vascular||Transient ischemic attack (Amaurosis fugax, Transient global amnesia) - Cerebrovascular disease (MCA, ACA, PCA, Foville's syndrome, Millard-Gubler syndrome, Lateral medullary syndrome, Weber's syndrome, Lacunar stroke)|
|Sleep disorders||Insomnia - Hypersomnia - Sleep apnea (Ondine's curse) - Narcolepsy - Cataplexy - Kleine-Levin syndrome - Circadian rhythm sleep disorder - Delayed sleep phase syndrome - Advanced sleep phase syndrome|
|Other||Hydrocephalus (Normal pressure) - Idiopathic intracranial hypertension - Encephalopathy - Brain herniation - Cerebral edema - Reye's syndrome - Syringomyelia - Syringobulbia - Spinal cord compression|