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Belatacept

Belatacept^?
Therapeutic monoclonal antibody
Source	recombinant
Target	CTLA 4
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Belatacept is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4 [1], which is a molecule crucial for T-cell costimulation, selectively blocking the process of T-cell activation. It was developed by Bristol-Myers-Squibb. It differs from abatacept (Orencia) by only 2 amino acids.

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It is intended to provide extended graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors.

v • d • e Immunomodulators - Immunosuppressants (L04)
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-imus	Abetimus, Difirolimus, Dofosirolimus, Everolimus, Gifosirolimus, Gusperimus, Pimecrolimus, Safosirolimus, Sirolimus, Tacrolimus, Temsirolimus, Torolimus, Zotarolimus
-cept (Fusion protein)	Abatacept, Alefacept, Belatacept, TNF inhibitor (Etanercept)
Other	Anakinra, Azathioprine, Ciclosporin, Leflunomide, Methotrexate, Mycophenolic acid, Thalidomide