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Pantherna Therapeutics is a privately-held biopharmaceutical Company developing first-in-class therapeutics for vascular diseases. Pantherna’s innovative technology platform is based on advanced nanoparticles for the delivery and expression of therapeutic mRNA drugs in the endothelium. Pantherna is more
Rigontec is a leader in the field of RIG-I-activating RNA therapeutics. Using our proprietary RIG-I agonist platform, we are taking advantage of one of the most important pathways of the innate immune system to develop a novel approach to cancer immunotherapy. Rigontec's proprietary agonists specifi more
Inflamalps is a biopharmaceutical company established in Valais, Switzerland Our mission is ‘’to discover and develop novel medicines to treat inflammation with a focus on chronic inflammatory diseases of the eye and of the skin” Our team comprises experienced pharmaceutical industry and biotechnolo more
Columbia University scientists, in collaboration with researchers from Harvard, have succeeded in developing a chemical process to convert visible light into infrared energy, allowing innocuous radiation to penetrate living tissue and other materials without the damage caused by high-intensity light more
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins. In the journal Angewandte Chemie, researchers r more
Nicolas Thomä's group at the FMI has joined forces with the group of Benjamin Ebert at Harvard’s Broad Institute to show how thalidomide analogs mediate degradation of many more proteins than previously anticipated. These proteins – zinc finger transcription factors – play a role in cancer and devel more
The xCELLigence system from Roche Applied Science, originally invented by the US company ACEA Biosciences, allows for label-free and dynamic monitoring of cell-based assays. The xCELLigence system utilizes impedance readout to non-invasively quantify more
To understand overall infectivity, virus progression and disease onset it is important to perform a detailed examination of cytopathic effects. Depending on the type of viruses and cells, different cytopathic effects might be observed dependent on th more
Looking for Biomarker quantification in microsampling support? Imperacer® enables target detection in low pg/ml range with lowest sample consumption. more
Preclinical development of drug candidates for Alzheimer’s disease (AD) takes multiple different paths; animal models are indispensable tools to support diverse preclinical drug development programs. Charles River performs in-house evaluations employing several mouse models
In vitro alternatives for toxicology screening and animal testing are increasing in variety. While validation against animal tests is costly and may result in false rejection, human clinical and/or mechanistic data is revolutionizing our acceptance and understanding of these
An important aspect of planning any biosimilar drug development program is the development and validation of robust bioanalytical assays to accompany nonclinical and clinical studies. Although many of these assays are not unique to biosimilar programs and follow regulatory guidelines in their respec
Sample-to-sample p-value variability and its implications for multivariate analysisWei Wang; Wilson Wen Bin GohInternational Journal of Bioinformatics Research and Applications, Vol. 14, No. 3 (2018) pp. 235 - 254Statistical feature selection is used for identification of relevant genes from biolog more
Viruses, Vol. 10, Pages 345: Delivering Phage Products to Combat Antibiotic Resistance in Developing Countries: Lessons Learned from the HIV/AIDS Epidemic in Africa Viruses doi: 10.3390/v10070345 Authors: Tobi E. Nagel The antimicrobial resistance (AMR) crisis and HIV/AIDS epidemic ex more
Pharmaceuticals, Vol. 11, Pages 64: Insights into Macrophage Heterogeneity and Cytokine-Induced Neuroinflammation in Major Depressive Disorder Pharmaceuticals doi: 10.3390/ph11030064 Authors: Adwitia Dey Pamela A. Hankey Giblin Over 350 million individuals suffer from depression, a more
GBI Research’s new report, “Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market”, presents various tools and strategies which can accelerate a drug to the market. In this report, GBI Research has studied various hurdles at diff more
Introduction Global Market Direct’s pharmaceuticals report, “XOMA Corporation - Product Pipeline Review - 2012” provides data on the XOMA Corporation’s research and development focus. The report includes information on current developmental pipeline, complete with latest updates, and features on d more
Introduction Global Market Direct’s pharmaceuticals report, “Orexo AB - Product Pipeline Review - 2012” provides data on the Orexo AB’s research and development focus. The report includes information on current developmental pipeline, complete with latest updates, and features on discontinued and more
Drug development Drug development or preclinical development is defined in many pharmaceutical companies as the process of taking a new chemical lead through the stages necessary to allow it to be tested in human clinical trial s, although a broa ... more
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