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Rigontec is a leader in the field of RIG-I-activating RNA therapeutics. Using our proprietary RIG-I agonist platform, we are taking advantage of one of the most important pathways of the innate immune system to develop a novel approach to cancer immunotherapy. Rigontec's proprietary agonists specifi more
Pantherna Therapeutics is a privately-held biopharmaceutical Company developing first-in-class therapeutics for vascular diseases. Pantherna’s innovative technology platform is based on advanced nanoparticles for the delivery and expression of therapeutic mRNA drugs in the endothelium. Pantherna is more
Inflamalps is a biopharmaceutical company established in Valais, Switzerland Our mission is ‘’to discover and develop novel medicines to treat inflammation with a focus on chronic inflammatory diseases of the eye and of the skin” Our team comprises experienced pharmaceutical industry and biotechnolo more
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins. In the journal Angewandte Chemie, researchers r more
Nicolas Thomä's group at the FMI has joined forces with the group of Benjamin Ebert at Harvard’s Broad Institute to show how thalidomide analogs mediate degradation of many more proteins than previously anticipated. These proteins – zinc finger transcription factors – play a role in cancer and devel more
A research group at Tohoku University has made a significant discovery with positive implications for the development of bacteria-fighting drugs. The aminoacyl-tRNA site (A-site) of the 16S RNA decoding region in the bacterial ribosome looks promising for a new era of antibiotic drug development. Tr more
The xCELLigence system from Roche Applied Science, originally invented by the US company ACEA Biosciences, allows for label-free and dynamic monitoring of cell-based assays. The xCELLigence system utilizes impedance readout to non-invasively quantify more
Roche’s xCELLigence Cardio Instrument is a medium-throughput cell analyzer using impedance recording to monitor cardiac beating and cellular events in real time. The instrument features high resolution detection rate and frequency measurement technol more
To understand overall infectivity, virus progression and disease onset it is important to perform a detailed examination of cytopathic effects. Depending on the type of viruses and cells, different cytopathic effects might be observed dependent on th more
Epitope binning describes segmentation of a panel of monoclonal antibodies into “bins” based upon the antigen region, or epitope, bound by the antibody using cross-competition assays. It is often performed in novel drug development, in generation of biosimilars, and in selecting reagents for sandwic
In vivo imaging techniques play an increasingly integral role in the drug development process. The applications of in vivo translational imaging are extending further into drug discovery and development and have the potential to considerably accelerate the process, reduce cost and increase 3Rs compl
With only 5% of cancer drugs being approved, the financial risks to oncology programs are huge. Recently, PDX (patient-derived xenografts) have become one of the preferred approaches for preclinical drug development and biomarker discovery, but when is the best time to introduce them into your progr
Sample-to-sample p-value variability and its implications for multivariate analysisWei Wang; Wilson Wen Bin GohInternational Journal of Bioinformatics Research and Applications, Vol. 14, No. 3 (2018) pp. 235 - 254Statistical feature selection is used for identification of relevant genes from biolog more
Viruses, Vol. 10, Pages 345: Delivering Phage Products to Combat Antibiotic Resistance in Developing Countries: Lessons Learned from the HIV/AIDS Epidemic in Africa Viruses doi: 10.3390/v10070345 Authors: Tobi E. Nagel The antimicrobial resistance (AMR) crisis and HIV/AIDS epidemic ex more
Pharmaceuticals, Vol. 11, Pages 64: Insights into Macrophage Heterogeneity and Cytokine-Induced Neuroinflammation in Major Depressive Disorder Pharmaceuticals doi: 10.3390/ph11030064 Authors: Adwitia Dey Pamela A. Hankey Giblin Over 350 million individuals suffer from depression, a more
GBI Research’s new report, “Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market”, presents various tools and strategies which can accelerate a drug to the market. In this report, GBI Research has studied various hurdles at diff more
Introduction Global Market Direct’s pharmaceuticals report, “XOMA Corporation - Product Pipeline Review - 2012” provides data on the XOMA Corporation’s research and development focus. The report includes information on current developmental pipeline, complete with latest updates, and features on d more
Introduction Global Market Direct’s pharmaceuticals report, “Orexo AB - Product Pipeline Review - 2012” provides data on the Orexo AB’s research and development focus. The report includes information on current developmental pipeline, complete with latest updates, and features on discontinued and more
Drug development Drug development or preclinical development is defined in many pharmaceutical companies as the process of taking a new chemical lead through the stages necessary to allow it to be tested in human clinical trial s, although a broa ... more
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