Affinity Resins

Products Affinity Resins

Increase throughput and robustness of your antibody purification

TOYOPEARL AF-rProtein A affinity resin is well-suited for capturing of antibodies out of high titre feedstocks more

Videos Affinity Resins

Increase throughput and robustness of your antibody purification

TOYOPEARL AF-rProtein A-650F combines a high binding capacity at short residence time and fast mass transfer kinetics with alkaline stability. Protein A based affinity chromatography is the industry standard for the capture of monoclonal antibodies (MAbs) in downstream processing. Rising fermentatio more

News Affinity Resins

• GE Healthcare and BAC collaborate to launch new bioprocess affinity resin

  GE Healthcare and BAC BV announced that, following a successful collaboration between the two companies, GE Healthcare Life Sciences has added a new affinity resin to its portfolio of technologies for the purification of antibody-based fragments. GE Healthcare’s new resin, LambdaFabSelect, is a desi more

• BAC Extends Partnership with GE Healthcare to Launch Alpha-1 Antitrypsin Select

  BAC BV has extended its collaboration with GE Healthcare with the addition of a new bioprocess affinity chromatography ligand to GE Healthcare’s range of custom designed media. The latest addition to the range is an affinity resin for the purification of alpha-1 antitrypsin (AAT) from blood plasma, more

• Nomad Bioscience: new plant biotechnology company founded to focus on biomaterials and biopharmaceuticals

  NOMAD Bioscience GmbH, Munich, Germany (NOMAD) is a private biotechnology company developing plant-made biomaterials and biopharmaceuticals that address critical unmet needs. NOMAD is developing a series of high-value products such as nanopatterned materials, protein scaffolds and templates, protein more

White papers Affinity Resins

• Increased productivity for downstream processing of biotherapeutics
  

  Polymer-based chromatographic resins featuring high mechanical and chemical stability and high protein binding capacities can help to increase the throughput and robustness of biopharmaceutical manufacturing processes. Advances in genetic engineering and cell culture technology have raised upstream productivity in the production of recombinant proteins. Increased titres of up to 10 g/l stress the need for highly efficient and robust downstream processes (DSP). Most industrial bioprocess development groups apply generic DSP platforms that are designed to purify various candidates of the same class of proteins applying the same process design. Besides various filtration and virus inactivation steps, they usually involve two or three chromatographic unit operations with orthogonal separation modes. The use of high capacity chromatographic resins can help to overcome the DSP bottleneck by increasing process throughput and robustness more

Publications Affinity Resins

• Cell‐free protein synthesis and purification of human dopamine D2L receptor

  Abstract The human dopamine D2L receptor has significant implications in neurological and neuropsychiatric disorders such as Parkinson's disease and schizophrenia. Detailed structural knowledge of this receptor is limited due to its highly hydrophobic nature, which leads to protein aggregation a more

• Large‐scale preparation of Shiga toxin 2 in Escherichia coli for toxoid vaccine antigen production

  ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) causes hemorrhagic colitis, and in more severe cases, a serious clinical complication called hemolytic uremic syndrome (HUS). One causative factor of HUS is Shiga toxin (Stx). Serotypes of Stx produced by EHEC include Stx1 and Stx2. Although so more

• Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress

  Upon DNA damage induction, DNA-dependent poly(ADP-ribose) polymerases (PARPs) synthesize an anionic poly(ADP-ribose) (pADPr) scaffold to which several proteins bind with the subsequent formation of pADPr-associated multiprotein complexes. We have used a combination of affinity-purification methods more

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