Tumor Growth

Obesity, which is on the rise worldwide, has been linked to colon cancer but the mechanism has been a mystery. In a new study, Yale researchers and their co-authors have uncovered how obesity drives tumor growth in mice, revealing potential strategies to combat the disease. Led by assistant professo more

Interstitial fluid transports nutrients and removes waste between the organs and tissues in our body. In the brain, interstitial fluid is thought to be composed of circulating cerebrospinal fluid, cellular waste and blood plasma, and past research has shown a link between interstitial fluid flow and more

Angiogenesis, the formation of new blood vessels, is essential for tumor growth. A new study describes a vascular stabilization biomarker that can visualize blood vessel activity, thus optimizing the timing of anticancer therapies including anti-angiogenics. Combination therapy using angiogenesis in more

Prostate cancer remains a leading cause of cancer death in the United States (1). In 2017, it was estimated that over 160,000 prostate cancer cases were diagnosed in the United States, and ∼26,000 men died of prostate cancer (2). Because tumor growth in prostate cancer is predominantly dependent on more

Although MK2 inhibition has been proposed as a therapy in cancer, its exact role, as well as the cellular and molecular mechanisms underlying it, in the intestine is not known. Here, we show that complete MK2 deletion leads to decreased epithelial cell proliferation, associated with reduced tumor gr more

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Ali Fan, Jiali Wei, Mengru Yang, Qing Zhang, Yaliang Zhang, Qingwang Liu, Ning Li, Di Zhao, Yang Lu, Junxiu Li, Jie Zhao, Shuhua Deng, Bingjie Zhang, Hailiang more