Phosphorylation

Chronobiologists at Ludwig-Maximilians-Universität (LMU) in Munich, Germany, show in two articles in the journal Science how critical the sleep-wake cycle is for protein and phosphorylation dynamics in synapses to ultimately regulate its activity. The internal clock controls virtually all physiologi more

Pharmacologists from Jena, Toulouse, St. Louis and Boca Raton as well as Montreal, Seattle and Mountain View were able to decipher the molecular behavior of the nociceptin receptor in cells and intact animals. Now published in Science Signaling, their research paper on the investigation of the fourt more

When bacteria or viruses enter the body, proteins on their surfaces are recognized and processed to activate T cells, white blood cells with critical roles in fighting infections. During T-cell activation, a molecular complex known as the microtubule-organizing center (MTOC) moves to a central locat more

by Yann Thomas, Daniel C. Scott, Yosua Adi Kristariyanto, Jesse Rinehart, Kristopher Clark, Philip Cohen, Thimo Kurz The activity of Cullin-RING ubiquitin E3 ligases (CRL) is regulated by NEDD8 modification. DCN-like proteins promote Cullin neddylation as scaffold-like E3s. One DCNL, DCNL5, is hi more

Vascular regeneration during retinal ischemia is critical for curtailing hypoxia-driven aberrant neovascularization and neuronal damage. Apoptotic cell death of astrocytes is a key initiating factor for improper vascular growth. Here we report that astrocytic connexin (Cx43) gap junction (GJ) channe more

by Lindsay McDonald, Mathieu Cayla, Alasdair Ivens, Binny Mony, Paula MacGregor, Eleanor Silvester, Kirsty McWilliam, Keith R. Matthews Trypanosoma brucei, the agents of African trypanosomiasis, undergo density-dependent differentiation in the mammalian bloodstream to prepare for transmission by more