Strength Training Activates Cellular Waste Disposal

Regulated degradation of damaged cell components prevents heart failure and nerve diseases

27-Aug-2024 - The elimination of damaged cell components is essential for the maintenance of the body’s tissues and organs. An international research team led by the University of Bonn has made significant findings on mechanisms for the clearing of cellular wastes, showing that strength training activates such ...

Lockdown for tumour cells

Novel inhibitor locks tumour cells in place

25-Apr-2022 - Protein phosphatases are the counterplayers of protein kinases and together, these two groups of enzymes control virtually every aspect of cellular behaviour. Therefore, being able to modulate the activity of specific kinases or phosphatases is the basis for a growing list of medical treatments, ...

Chronobiology: Sleep and synaptic rhythms

15-Oct-2019 - Chronobiologists at Ludwig-Maximilians-Universität (LMU) in Munich, Germany, show in two articles in the journal Science how critical the sleep-wake cycle is for protein and phosphorylation dynamics in synapses to ultimately regulate its activity. The internal clock controls virtually all ...

The pharmacological “fingerprint“ of the fourth opioid receptor

28-Mar-2019 - Pharmacologists from Jena, Toulouse, St. Louis and Boca Raton as well as Montreal, Seattle and Mountain View were able to decipher the molecular behavior of the nociceptin receptor in cells and intact animals. Now published in Science Signaling, their research paper on the investigation of the ...

A new molecular player involved in T cell activation

13-Dec-2018 - When bacteria or viruses enter the body, proteins on their surfaces are recognized and processed to activate T cells, white blood cells with critical roles in fighting infections. During T-cell activation, a molecular complex known as the microtubule-organizing center (MTOC) moves to a central ...

How the food we eat affects biochemical signals in the gut

07-Jun-2018 - For years, researchers have studied how the body's microbiome impacts virtually every aspect of human health ranging from the immune system to mental wellness. Now, a recent study led by a multi-institutional research team, including the University of Maryland, several institutions in South ...

Newly discovered protein prevents undisturbed proliferation of cancer cells

23-Mar-2018 - An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can ...

Heart-muscle patches made with human cells improve heart attack recovery

12-Jan-2018 - Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery from heart attack injury. The results are a step closer to the goal of ...

Potential 'missing link' in chemistry that led to life on earth found

08-Nov-2017 - Chemists at The Scripps Research Institute (TSRI) have found a compound that may have been a crucial factor in the origins of life on Earth. Origins-of-life researchers have hypothesized that a chemical reaction called phosphorylation may have been crucial for the assembly of three key ...

Many proteins must set to work so as to activate fat

New insights into the fuctions of fat metabolism

15-Aug-2017 - What happens and where, when the body’s fat stores are activated? With the support of the Austrian Science Fund FWF, the biochemist Ruth Birner-Grünberger investigates the complex interaction of activation and regulation in fat breakdown, thus providing a basis for new therapeutic approaches for ...