PEGylation

MIT researchers have devised a way to make tumor cells more susceptible to certain types of cancer treatment by coating the cells with nanoparticles before delivering drugs. By tethering hundreds of tiny particles to the surfaces of tumor cells in the presence of a mechanical force, the researchers more

Positron emission tomography plays a pivotal role for monitoring the distribution and accumulation of radiolabeled nanomaterials in living subjects. The radioactive metals are usually connected to the nanomaterial through an anchor, a so-called chelator, but this chemical binding can be omitted if n more

Biomedical engineers at Duke University have reconfigured a popular drug-delivery technology to evade immune responses that have halted some clinical trials. Polyethylene glycol, commonly known as PEG, is a polymer commonly found in commercial products from toothpaste to cosmetics, and also in pharm more

As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace more

Pharmaceuticals, Vol. 11, Pages 9: Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine Pharmaceuticals doi: 10.3390/ph11010009 Authors: Yusuke Kamiya Tsutomu Yamaki Shigehiro Omori Masaki Uchida Kazuo Ohtake Mitsutoshi Kimura Hiros more

Publication date: 1 January 2018 Source:European Journal of Pharmaceutical Sciences, Volume 111 Author(s): Alessandro Venuta, Francesca Moret, Giovanni Dal Poggetto, Diletta Esposito, Aurore Fraix, Concetta Avitabile, Francesca Ungaro, Mario Malinconico, Salvatore Sortino, Al more

This study aims to develop a new folate receptor (FR)-targeting agent for SPECT imaging with improved contrast and evaluate the modification strategies of multimerization and/or PEGylation in the development of new radio-folates. A series of novel folate derivatives have been synthesized and radiola more