A promising investigational therapeutic monoclonal antibody to treat chronic hepatitis B and D infections

08-Aug-2023 - Affecting hundreds of millions of people, chronic hepatitis B is a widespread global health problem for which there is as yet no cure. In a preclinical study involving the German Center for Infection Research (DZIF), Heidelberg University Hospital, University Medical Center Hamburg-Eppendorf and ...

WildDISCO: Visualizing Whole Bodies in Unprecedented Detail

AI Integration: Predicting Disease Progression Without the Use of Animal Models in Research

12-Jul-2023 - Researchers developed a new method called wildDISCO that uses standard antibodies to map the entire body of an animal using fluorescent markers. This revolutionary technique provides detailed 3D maps of structures, shedding new light on complex biological systems and diseases. WildDISCO has the ...

Fintetuning for antibodies

The strength of the immune reaction triggered by antibodies can be regulated

11-Jul-2023 - Antibodies are crucial, not only for treating tumors and infections. Sometimes, however, the immune reaction they trigger can be too strong and end up causing more damage, for example in the case of people infected with Covid-19. Problems such as these can often be avoided by finetuning ...

Deadly virus structures point toward new avenues for vaccine design

By comparing the structures of protein complexes from different lineages of the dangerous Lassa virus, a Scripps Research team identified new antibodies and vaccine targets

12-Jun-2023 - Every year, hundreds of thousands of people in West Africa become infected with Lassa virus, which can cause Lassa fever and lead to severe illness, long-term side effects or death. There are currently no widely approved treatments or vaccines for the disease. Now, scientists at Scripps Research ...

Waters and Sartorius Expand Collaboration to Deliver Comprehensive Bioanalytics for Downstream Biomanufacturing

06-Jun-2023 - Waters Corporation and Sartorius announced a new collaboration to develop integrated analytical solutions for downstream biomanufacturing, expanding their joint agreement that began with upstream bioprocessing analytics. Software and hardware integrations between the Waters™ PATROL™ ...

Putting an end to rheumatoid arthritis?

Interdisciplinary research team unlocks the mechanism for inhibiting inflammation of the joints

12-May-2023 - Immunoglobulin G antibodies (IgG) play an important role as drivers of inflammation in infectious diseases and autoimmune diseases. However, if the same immunoglobulin antibodies from the blood plasma of healthy donors are cleansed and injected into a patient’s bloodstream, they exhibit ...

Are autoantibodies in COVID-19 less harmful than previously thought?

In most cases they are likely not to blame when patients become severely ill

06-Apr-2023 - Critically ill COVID-19 patients often have antibodies in their blood that bind to the body’s own structures, so-called autoantibodies. Scientists from the BIH at Charité and the Max Delbrück Center have now discovered that these autoantibodies frequently bind to not just one but multiple ...

New checkpoint antibody against cancer

BioNTech and OncoC4 announce strategic collaboration

22-Mar-2023 - BioNTech SE and OncoC4, Inc., a clinical-stage biopharmaceutical company dedicated to the discovery and development of novel biologicals for cancer treatment, announced that they have entered into an exclusive worldwide license and collaboration agreement to develop and commercialize OncoC4’s ...

Precise attack on tumor remnants

Targeting brain tumors: new drug candidate in clinical trial

15-Mar-2023 - Clinical trials are a milestone in the development of safe and effective drugs and therapies. An antibody developed by Helmholtz Munich is now entering a phase 1 clinical trial. Together with the radiopharmaceutical company ITM Isotope Technologies Munich and Münster University Hospital, ...

Enhancing at-home COVID tests with glow-in-the dark materials

09-Mar-2023 - Researchers at the University of Houston are using glow-in-the-dark materials to enhance and improve rapid COVID-19 home tests. If you’ve taken an at-home COVID-19 or pregnancy test, then you’ve taken what is scientifically called a lateral flow assay (LFA) test, a diagnostic tool widely used ...