Synthesis - 29 News by Max-Planck-Gesellschaft

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Synthesis - 29 News by Max-Planck-Gesellschaft

Tip: You can further refine your news selection by industries.

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First synthesis of open-chain N-stereogenic amines achieved

Study enables enantiomerically pure products for drug development.

26-Nov-2025 - Researchers at the Max Planck Institut für Kohlenforschung have developed a method for synthesizing stable, chiral open-chain amines with chirality on nitrogen, a previously elusive task. Their work utilizes a new catalytic reaction with a confined chiral catalyst. A research team from Prof. ...

synthesis amines catalysis
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Two plant species invent the same chemically complex and medically interesting substance

Different building blocks: The plants use similar chemical pathways to biosynthesize these compounds, but use different starting materials and enzymes

06-Jun-2025 - A team of researchers from the Max Planck Institute for Chemical Ecology collaborated with international colleagues to study the biosynthesis of ipecacuanha alkaloids. They compared two plant species and discovered that, despite using similar chemical approaches, the species employ different ...

synthesis alkaloids biosynthesis
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Electrochemistry Paves the Way: Sustainable Synthesis Method Reveals N-Hydroxy Modifications for Pharmaceuticals

Closing knowledge gaps - new findings on heterocycles

18-Apr-2024 - New highly selective and scalable electro-organic synthesis of novel benzo[e]-1,2,4-thiadiazine-1,1-dioxides which represent an important structural motif of APIs (active pharmaceutical ingredients) modified with a unique N-hydroxy moiety. Recently published research results enable preparative ...

synthesis drug design electrochemistry
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Thianthrenium chemistry allows for reactivity switch of a nucleophilic amino acid into a versatile intermediate

Useful and broadly applicable tool in the field of chemical biology

03-Jan-2024 - Chemical diversification of proteins is an important concept in the study of biological processes and the complex structures of the proteins themselves. It involves using quick and mild reactions that selectively target a specific amino acid and therefore a building block of proteins. Cysteine is ...

synthesis amino acids chemical biology
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Scientists discover how yew trees save lives

Complete biosynthetic pathway for one of the world's most successful chemotherapeutics revealed

14-Dec-2023 - Researchers from the Max Planck Institute of Molecular Plant Physiology unravel the biosynthetic pathway of paclitaxel in Yew plants, a most successfully used chemotherapeutic for cancer treatment. This discovery might facilitate the production of this very complex molecule which is currently ...

synthesis biosynthesis cancer
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Cell-free quest for new antibiotics

A new method combines synthetic biology with artificial intelligence

20-Nov-2023 - The rising resistance of bacteria to antibiotics presents an escalating global health risk. Now, researchers at the Max Planck Institute for Terrestrial Microbiology have combined synthetic biology and artificial intelligence (AI) to develop a more efficient approach to finding and creating new ...

synthesis antibiotic resistance antibiotics
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Fatty acid factory filmed at work

High-resolution images provide new insights into cellular fatty acid production: Potential for medicine and biotechnology

15-Nov-2023 - Fatty acids are essential in all living organisms: to store energy, form membranes, and multiply. They are produced by a complex cellular machinery – the fatty acid synthase (FAS). A team of the Max Planck Institute (MPI) for Multidisciplinary Sciences, led by Ashwin Chari and Holger Stark, have ...

synthesis biosynthesis cryo-electron microscopy
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New Discovery: Toward sugar origami

Folded carbohydrates could open up completely new perspectives in biomedicine and materials science

06-Jul-2023 - Researchers at the Max Planck Institute of Colloids and Interfaces (MPICI) have designed a carbohydrate sequence capable of folding into a stable secondary structure. Until now, such self-folding biopolymers had only been developed for DNA and proteins, and sugars were previously considered too ...

synthesis biomedicine carbohydrates
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Analysis of single plant cells provides insights into natural product biosynthesis

Single-cell multi-omics reveals that cell types are differentially involved in the production and accumulation of medically relevant plant compounds

19-May-2023 - In a new study published in Nature Chemical Biology, an international team of researchers from the University of Georgia, USA, and the Max Planck Institute for Chemical Ecology in Jena, Germany, presents a promising strategy for elucidating metabolic pathways for plant compounds of medicinal ...

synthesis active ingredients alkaloids
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Back to the Future of Photosynthesis

Scientific journeys back in time can provide invaluable insights for the future

17-Oct-2022 - The central biocatalyst in Photosynthesis, Rubisco, is the most abundant enzyme on earth. But how did Rubisco evolve, and how did it adapt to environmental changes during Earth’s history? By reconstructing billion-year-old enzymes, a team of Max Planck Researchers has deciphered one of the key ...

synthesis enzymes evolution
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