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€ 1 Million Research Grant Awarded for the First Time

Merck awarded a grant known as the Future Insight Prize for the first time

11-Jul-2019

Merck awarded a grant known as the Future Insight Prize for the first time. Pardis Sabeti, Harvard University and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA, and James Crowe, Vanderbilt University Medical Center, Nashville, Tennessee, USA, were recognized for their ...

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Evolution of a deadly virus

Genomic sequences reveal that Florida is a major source of a mosquito-borne virus

25-May-2018

Infections caused by the mosquito-borne eastern equine encephalitis virus (EEEV) are severe and have high mortality rates for horses - 90 percent - and humans - 33 percent, with significant brain damage in most human survivors. Florida has been hypothesized to be the source of EEEV epidemics, but ...

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New view of the heartbeat

10-Apr-2018

The human cardiac voltage-gated sodium channel (Nav1.5) plays a critical role in maintaining regular heartbeats. Mutations in Nav1.5 cause life-threatening heart rhythm disorders (arrhythmias). Nav1.5 is sensitive to the calcium-ion sensor protein calmodulin (CaM); however, the exact mechanism of ...

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Tracking protein’s role in stem cell function

26-Mar-2018

MCL-1 is a member of the BCL-2 family of proteins important for blocking apoptosis, or programmed cell death. Many types of cancer cells escape the body’s effort to kill them by overexpressing MCL-1. However, new evidence from Vanderbilt University researchers indicates that MCL-1 also helps ...

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A lipid’s role in cell division

14-Nov-2017

Proper cell division is a basic process critical to cell survival. A ring composed of actin filaments and myosin motor proteins pinches the cell apart, producing two daughter cells with equal amounts of cellular components. Kathleen Gould , Ph.D., and colleagues characterized how this powerful ...

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New tools to combat kidney fibrosis

16-Oct-2017

Interstitial fibrosis – excessive tissue scarring – contributes to chronic kidney disease, which is increasing in prevalence in the United States. Raymond Harris , M.D., and colleagues have previously implicated the epidermal growth factor receptor (EGFR) in the pathogenesis of diabetic ...

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Inhibiting obesity

18-Sep-2017

NAPEs, a family of lipid molecules, are produced in the intestinal tract after food intake and exert leptin-like effects: they reduce food intake and weight gain. Given their potential importance in regulating satiety and inhibiting obesity, Sean Davies , Ph.D., and colleagues are exploring NAPE ...

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Combination therapy PrEP offers effective way to prevent HIV infection

11-Sep-2017

Rates of new HIV infections in the United States are declining — except among men who have sex with men. Rates are particularly high among African-American and Hispanic men and especially in the South. Currently, one in six men who have sex with men can expect to be diagnosed with HIV in their ...

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High-salt diet decreases thirst, increases hunger

19-Apr-2017

When you eat salty food, you get thirsty and drink water. Right? Maybe in the short-term, but within 24 hours, you actually get less thirsty because your body starts to conserve and produce more water. This counterintuitive discovery by scientists at Vanderbilt University and in Germany has ...

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Blocking neuroblastoma cell growth

An inhibitor of cell metabolism may be a good therapeutic target for neuroblastoma

24-Mar-2017

Neuroblastoma – a cancer that starts in nerve tissue outside of the brain – is the third most common cancer in children and accounts for about 15 percent of pediatric cancer-related deaths. MYC proteins drive neuroblastoma tumorigenesis in part by promoting the expression of key glycolytic ...

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