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59 Current news of Vanderbilt University

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Fish eyes may hold key to regenerating human retinas

13-Mar-2017

If you were a fish and your retina was damaged, it could repair itself and your vision would be restored in a few weeks. Sadly, human eyes don’t have this beneficial ability. However, new research into retinal regeneration in zebrafish has identified a signal that appears to trigger the ...

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Melanoma study finds new way to enhance targeted therapies

13-Mar-2017

With the help of a drug formerly used to treat HIV/AIDS, researchers at Vanderbilt University Medical Center (VUMC) have found a way to make melanoma cells more vulnerable to targeted anti-cancer therapy. Since the AIDS drug is already FDA approved, clinical testing in melanoma patients could ...

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Organ-on-a-chip mimics heart's biomechanical properties

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24-Feb-2017

The human heart beats more than 2.5 billion times in an average lifetime. Now scientists at Vanderbilt University have created a three-dimensional organ-on-a-chip that can mimic the heart's amazing biomechanical properties. "We created the I-Wire Heart-on-a-Chip so that we can understand why ...

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Improving therapies for GI tumors

22-Feb-2017

The signaling protein Aurora kinase A (AURKA) is overexpressed in several cancer types and has diverse oncogenic functions, making it an attractive druggable cancer target. Wael El-Rifai , M.D., Ph.D., and colleagues are exploring a role for AURKA in upper gastrointestinal cancers, which are ...

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Cellular responses to bird flu vaccine uncovered

20-Feb-2017

New research from Vanderbilt University eavesdrops on gene expression in human immune system cells before and after vaccination against bird flu. The study exposes cellular responses associated with a vaccine constituent called AS03, short for adjuvant system 03. Using massive computation, the ...

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Improving vaccine formulations

24-Jan-2017

Vaccines help prevent and fight infections, but they need extra help from added “adjuvants” to elicit a robust immune response. Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, activates the innate immune system when it binds to the toll-like receptor 4 ...

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Faster (cheaper) method for making big bioactive ring molecules

14-Dec-2016

Ring molecules called cyclic depsipeptides play an important role in living organisms. Microbes make them as part of their chemical arsenal for attacking competitors and they have proven effective as antibiotics, anti-retrovirals and pesticides, among other applications. One problem, however, has ...

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Experimental insecticide explodes mosquitoes, not honeybees

07-Dec-2016

In a new study, Vanderbilt pharmacologist Jerod Denton, Ph.D., Ohio State entomologist Peter Piermarini, Ph.D., and colleagues report an experimental molecule that inhibits kidney function in mosquitoes and thus might provide a new way to control the deadliest animal on Earth. The investigators ...

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Targeting the “un-targetable”

Targeting the protein RSK blocked aggressive breast cancers from metastasizing in an animal model.

22-Nov-2016

Triple negative breast cancers (TNBC) are so named because they lack common genetic “target” mutations that can be easily treated with specific cancer drugs. However Deborah Lannigan , Ph.D., and colleagues investigated a new target involved in TNBC called RSK. They demonstrated that RSK can help ...

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Alzheimer’s study establishes way to measure resilience

14-Nov-2016

Vanderbilt researchers have established a new measure of resilience to cognitive impairment in people with asymptomatic Alzheimer’s disease. They essentially flipped the standard approach used by researchers when mining the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, said Timothy ...

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