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An inhibitor of cell metabolism may be a good therapeutic target for neuroblastoma
24-Mar-2017 - Neuroblastoma – a cancer that starts in nerve tissue outside of the brain – is the third most common cancer in children and accounts for about 15 percent of pediatric cancer-related deaths. MYC proteins drive neuroblastoma tumorigenesis in part by promoting the expression of key glycolytic ...
13-Mar-2017 - If you were a fish and your retina was damaged, it could repair itself and your vision would be restored in a few weeks. Sadly, human eyes don’t have this beneficial ability. However, new research into retinal regeneration in zebrafish has identified a signal that appears to trigger the ...
13-Mar-2017 - With the help of a drug formerly used to treat HIV/AIDS, researchers at Vanderbilt University Medical Center (VUMC) have found a way to make melanoma cells more vulnerable to targeted anti-cancer therapy. Since the AIDS drug is already FDA approved, clinical testing in melanoma patients could ...
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24-Feb-2017 - The human heart beats more than 2.5 billion times in an average lifetime. Now scientists at Vanderbilt University have created a three-dimensional organ-on-a-chip that can mimic the heart's amazing biomechanical properties. "We created the I-Wire Heart-on-a-Chip so that we can understand why ...
22-Feb-2017 - The signaling protein Aurora kinase A (AURKA) is overexpressed in several cancer types and has diverse oncogenic functions, making it an attractive druggable cancer target. Wael El-Rifai , M.D., Ph.D., and colleagues are exploring a role for AURKA in upper gastrointestinal cancers, which are ...
20-Feb-2017 - New research from Vanderbilt University eavesdrops on gene expression in human immune system cells before and after vaccination against bird flu. The study exposes cellular responses associated with a vaccine constituent called AS03, short for adjuvant system 03. Using massive computation, the ...
24-Jan-2017 - Vaccines help prevent and fight infections, but they need extra help from added “adjuvants” to elicit a robust immune response. Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, activates the innate immune system when it binds to the toll-like receptor 4 ...
14-Dec-2016 - Ring molecules called cyclic depsipeptides play an important role in living organisms. Microbes make them as part of their chemical arsenal for attacking competitors and they have proven effective as antibiotics, anti-retrovirals and pesticides, among other applications. One problem, however, has ...
07-Dec-2016 - In a new study, Vanderbilt pharmacologist Jerod Denton, Ph.D., Ohio State entomologist Peter Piermarini, Ph.D., and colleagues report an experimental molecule that inhibits kidney function in mosquitoes and thus might provide a new way to control the deadliest animal on Earth. The investigators ...
Targeting the protein RSK blocked aggressive breast cancers from metastasizing in an animal model.
22-Nov-2016 - Triple negative breast cancers (TNBC) are so named because they lack common genetic “target” mutations that can be easily treated with specific cancer drugs. However Deborah Lannigan , Ph.D., and colleagues investigated a new target involved in TNBC called RSK. They demonstrated that RSK can help ...
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