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A 3D printed vaccine patch offers vaccination without a shot

Scientists develop microneedle vaccine patch that outperforms needle jab to boost immunity

28-Sep-2021

Scientists at Stanford University and theUniversity of North Carolina at Chapel Hill have created a 3D-printed vaccine patch that provides greater protection than a typical vaccine shot. The trick is applying the vaccine patch directly to the skin, which is full of immune cells that vaccines ...

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AI algorithm solves structural biology challenges

Researchers develop machine learning methods that accurately predict the 3D shapes of drug targets and other important biological molecules, even when only limited data is available

02-Sep-2021

Determining the 3D shapes of biological molecules is one of the hardest problems in modern biology and medical discovery. Companies and research institutions often spend millions of dollars to determine a molecular structure – and even such massive efforts are frequently unsuccessful. Using ...

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Evonik to market and develop new drug delivery platform for mRNA and gene therapy

Evonik and Stanford University sign research collaboration

11-Jun-2021

Evonik is working with Stanford University on a technology to deliver mRNA to tissues and organs that goes beyond the capabilities of lipid nanoparticles (LNPs). This polymer-based platform complements Evonik’s existing portfolio of lipid-based drug delivery, including LNPs. Starting this month, ...

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Covid-19 can trigger diabetes

When SARS-CoV-2 infects beta cells, they produce less insulin and show signs of death

03-Jun-2021

Some Covid-19 patients develop diabetes in the course of their infection. An international study with participation by the University of Basel has mapped how coronavirus attacks and destroys insulin-producing pancreatic cells. The researchers also identified a way to protect these cells. Diabetes ...

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Allergic immune responses help fight bacterial infections

Exciting discovery could also explain why the body has maintained the “allergy module” throughout evolution

11-Sep-2020

Researchers from CeMM Research Center of Molecular Medicine of the Austrian Academy of Sciences, the Medical University of Vienna and Stanford University School of Medicine, have found that a module of the immune system, which is best known for causing allergic reactions, plays a key role in ...

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How to Put Neurons into Cages

Using an acoustic bioprinting technology it was possible to develop multicellular nerve tissue

05-May-2020

Using microscopically fine 3D printing technologies from TU Wien (Vienna) and sound waves used as tweezers at Stanford University (California), tiny networks of neurons have been created. Microscopically small cages can be produced at TU Wien (Vienna). Their grid openings are only a few ...

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New CRISPR-based tool can probe and control several genetic circuits at once

Technology allows for greater precision in identifying and treating diseased cells

18-Feb-2020

Every cell in our body has a computer-like control system that sends biological signals through thousands of circuits to monitor the cell's needs and regulate its responses. But when diseases such as cancer arise, these regulatory circuits often go awry, resulting in unnatural signals and ...

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Pathogens find safe harbor deep in the gastric glands

06-May-2019

Scientists have long tried to understand how pathogenic bacteria like Helicobacter pylori, a risk factor for stomach ulcers and cancer, survive in the harsh environment of the stomach. In a new study in the open-access journal PLOS Biology, researchers led by Connie Fung and Manuel Amieva at ...

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Protein complex prevents toxic aggregation of proteins

16-Apr-2019

A protein complex within the cell has been found to play a key role in preventing the toxicity of proteins which build up amyloid plaques and can lead to neurodegenerative disorders such as Alzheimer’s and Huntington’s disease. Researchers from the Universities of Konstanz (Germany), Leeds (UK) ...

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CRISPR-Cas9 corrects sickle cell mutation

Collaborative effort to reduce off-target CRISPR-Cas9 genome editing

08-Aug-2018

Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells. Prior to adoption as a medical therapeutic, safety concerns relating to off-target effects must be minimized to mitigate risks that may arise from the unintended action ...

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