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12 Current news of max-planck-institut-fuer-multidisziplinaere-naturwissenschaften

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NovAliX and Max Planck join forces to advance Cryo-EM driven drug discovery

Collaboration will make vital process of translating scientific research and academic insights into real therapies more efficient and more effective

07-Mar-2024 - NovAliX, a specialized Contract Research Organization dedicated to enabling drug discovery, announces its long-term strategic partnership with the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen. Through this collaboration, NovAliX and the MPI aim to make the vital process ...

cryo-electron microscopy drug development drug discovery
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Shredding to plan – protein recycling for immune defense

“If we know how the proteasome generates immunopeptides, we can predict peptide splicing. In future, these predictions could, in turn, help develop novel vaccines against cancer or infectious diseases”

16-Feb-2024 - The waste system of living cells, the proteasome, not only shreds disused or damaged proteins. It also supports the immune system in recognizing virally infected or cancerous cells by producing protein fragments, so-called immunopeptides. In an international collaboration, researchers led by ...

cancer immune system immunopeptides +5
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It is in our genes – and how our genome folds in 3D

New findings could help in the prevention and treatment of diseases

01-Feb-2024 - Whether we stay healthy or become seriously ill is determined by our genes. But also, the folding of our genome has a significant influence on this, as the 3D genome organization regulates which genes are switched on and off. Researchers led by Marieke Oudelaar and Elisa Oberbeckmann at the Max ...

chromatin DNA DNA folding +3
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How HIV smuggles its genetic material into the cell nucleus

New discovery might one day be exploited for better AIDS therapies

30-Jan-2024 - Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year. To replicate and spread the infection, the virus must smuggle its genetic material into the cell nucleus and integrate it into a chromosome. Research teams led by Dirk Görlich at the Max ...

AIDS capsids cell nucleus +2
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Nanoparticles for optimized cancer therapy

Innovative method holds promise for more targeted treatment with fewer side effects - spin-off aims to quickly bring nanoparticles into clinical use

17-Nov-2023 - Pancreatic cancer is one of the deadliest types of cancers in humans. It is the fourth leading cause of cancer-related deaths in the western world. The early stages of the disease often progress without symptoms, so diagnosis is usually very late. Another problem: Advanced tumors – and their ...

cancer cancer therapy drug release +2
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Fatty acid factory filmed at work

High-resolution images provide new insights into cellular fatty acid production: Potential for medicine and biotechnology

15-Nov-2023 - Fatty acids are essential in all living organisms: to store energy, form membranes, and multiply. They are produced by a complex cellular machinery – the fatty acid synthase (FAS). A team of the Max Planck Institute (MPI) for Multidisciplinary Sciences, led by Ashwin Chari and Holger Stark, have ...

biosynthesis cryo-electron microscopy enzymatic reactions +3
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Poorly insulated nerve cells promote Alzheimer’s disease in old age

The results of the study show, for the first time, that defective myelin in the aging brain increases the risk of Aꞵ peptide deposition

08-Jun-2023 - Alzheimer’s disease, an irreversible form of dementia, is considered the world’s most common neurodegenerative disease. The prime risk factor for Alzheimer’s is age, although it remains unclear why. It is known that the insulating layer around nerve cells in the brain, named myelin, degenerates ...

Alzheimer's disease beta-Amyloid plaques brain +6
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Discovery in Parkinson’s research: Lipids influence the formation of protein clumps

Findings could open new approaches to diagnosing and treating Parkinson’s disease

17-Nov-2022 - After Alzheimer’s, Parkinson’s is the most common neurodegenerative disease in the world. More than six million people worldwide suffer from it. In this disease, alpha-synuclein proteins form thread-like structures called fibrils. When these fibrils clump together, they probably damage nerve ...

alpha-Synuclein fibrils lipids +4
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Novel sensors enable precise measurement of dopamine

Carbon nanotubes glow brighter in the presence of neurotransmitters. This facilitates the easy and accurate measurement of signals between nerve cells

30-May-2022 - Dopamine is an important signalling molecule for nerve cells. Its concentration could not be precisely determined with both high spatial or temporal resolution until now. A new method has now made this possible: A research team from Bochum, Göttingen and Duisburg used modified carbon nanotubes ...

carbon nanotubes dopamine fluorescence +4
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Research describes fundamental principle of enzyme catalysis

How equal charges in enzymes control biochemical reactions

26-Apr-2022 - It is well known in physics and chemistry that equal charges repel each other, while opposite charges attract. It was long assumed that this principle also applies when enzymes – the biological catalysts in all living organisms – form or break chemical bonds. It was thought that enzymes place ...

chemical reactions enzymatic catalysis enzymes +1