Brain - 16 News by Deutsches Zentrum für Neurodegenerative Erkrankungen
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“Viral relicts” in the Genome Could Fuel Neurodegeneration
Researchers see ancient genes as potential targets for dementia treatment
24-Aug-2023 - Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers at DZNE come to this conclusion on the basis of studies on cell cultures. They report on this in the journal Nature Communications. In their view, ...
A Varied Life Boosts the Brain’s Functional Networks
Results from a mouse study with novel biosensing technique
17-Jul-2023 - That experiences leave their trace in the connectivity of the brain has been known for a while, but a pioneering study by researchers at the German Center for Neurodegenerative Diseases (DZNE) and TUD Dresden University of Technology now shows how massive these effects really are. The findings in ...
New target for Alzheimer's therapies found
Researchers discover link between the protein medin and Alzheimer's disease
22-Nov-2022 - The protein medin is deposited in the blood vessels of the brains of Alzheimer's patients along with the protein amyloid-β. Researchers from DZNE have discovered this so-called co-aggregation. They have now published their observation in the journal Nature. "Medin has been known for over 20 ...
Drug Testing with Artificial Brain Vessels
Screening method simulates filter effect of the “blood-brain barrier”
05-Sep-2022 - In the journal “Biomaterials”, DZNE researchers present a novel method for testing chemical agents that could help in the development of drugs against neurodegenerative diseases. This analytical technique allows to study in the laboratory whether new drug candidates have a realistic chance of ...
More Brain Lesions in Senior Women than in Men of the Same Age
The Extent of Abnormalities in the Brain’s White Matter Grows Significantly After Menopause
04-Jul-2022 - In women after menopause, the extent of certain brain lesions is larger than in men of the same age. DZNE researchers come to this conclusion based on the assessment of more than 3,400 adults as part of the Bonn Rhineland Study. A team led by neuroscientist Monique Breteler reports on the ...
Alzheimer’s: Protective Immune Cells Active Decades Before Symptom Onset
Boosting the Brain’s Defenses Could Help Combat the Disease
23-Mar-2022 - In individuals with a genetic predisposition to Alzheimer’s disease, the immune cells of the brain – the “microglia” – start exerting a protective effect up to two decades before the first symptoms appear. A team from Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and ...
The Retina as a Potential Biomarker for Reduced Brain Matter
“There is evidence that the retina can serve as a window into the brain”
17-Mar-2022 - Researchers from the Department of Ophthalmology at the University Hospital Bonn (UKB) and Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) have found a close connection between the dimensions of retinal structures and those of the brain. They report on this in the journal “Scientific ...
Highly Responsive Immune Cells Seem to be Beneficial for the Brain
New Insights into the Mechanisms of Neurodegenerative Diseases.
16-Feb-2022 - Findings by researchers from Germany support the view that hyperactive immune cells in the brain can have a protective effect in the course of neurodegenerative diseases. Experts from Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ludwig-Maximilians-Universität München (LMU) and LMU ...
In neurodegenerative diseases, brain immune cells have a “ravenous appetite” for sugar
The interpretation of certain brain scans needs rethinking
15-Oct-2021 - At the beginning of neurodegenerative disease, the immune cells of the brain – the “microglia” – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed. Studies by the DZNE, the LMU München and the LMU Klinikum München, published in the journal Science Translational ...
Cleaning craze in the brain
Synaptic protein waste" was collected more quickly when the presynaptic protein bassoon is missing
28-May-2020 - Synapses consist of hundreds of different proteins. For correct transmission of brain signals, their building blocks must constantly be checked for functionality and replaced by new ones. A team of researchers from the Leibniz Institute of Neurobiology Magdeburg, the German Centre for ...
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