Basilea initiates phase I clinical program of its novel antibiotic BAL30072
"Basilea remains focused on developing novel hospital anti-infectives targeting the medical challenge of rising drug resistance. We are delighted to see this innovative antibiotic move forward from Basilea's own research as the third anti-infective in our clinical development pipeline," said Dr. Anthony Man, CEO of Basilea Pharmaceutica Ltd. "BAL30072 is designed to tackle the increasing problem of antibiotic-resistance in a broad range of Gram-negative bacteria associated with a wide variety of serious and life-threatening hospital infections."
The double-blind, randomized, placebo-controlled clinical phase I study investigates the pharmacokinetics, safety and tolerability of single ascending doses of BAL30072 in healthy male volunteers.
BAL30072 is a novel siderophore (iron-binding) sulfactam antibiotic with a unique mode of action, conferring potent bactericidal activity against Gram-negative pathogens. The compound can act like a "Trojan horse" by exploiting natural nutrient uptake systems of pathogens to gain access to its intracellular target.
BAL30072 is stable towards many types of beta-lactamase enzymes, including many of the extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases, which can deactivate most of the currently marketed beta-lactam antibiotics such as cephalosporins and carbapenems. The compound demonstrates potent antibacterial in-vitro and in-vivo activity against clinically increasingly problematic multi-resistant Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter spp., Klebsiella spp. and Enterobacter spp. These pathogens are associated with serious and life-threatening infections, including hospital-acquired pneumonia, complicated intra-abdominal infections or complicated urinary tract infections.
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