14-Jun-2010 - Silence Therapeutics plc

Silence Therapeutics Announces Issuance of Patent Covering Methods for Enhancing Silencing Activity of RNAi Therapeutics

Patent Covers Structural Modifications Associated with Innovative Zamore 'Design Rules'

Silence Therapeutics plc announced the issuance of United States patent 7,732,593, titled Methods and Compositions For Controlling Efficacy of RNA Silencing, by the United States Patent and Trademark Office (USPTO). The issued patent, which is based on the seminal research of Phillip D. Zamore, Ph.D., Howard Hughes Medical Institute Investigator, the Gretchen Stone Cook Chair of Biomedical Sciences, and Professor of Biochemistry & Molecular Pharmacology at University of Massachusetts Medical School, generally claims methods of enhancing the RNA silencing activity of RNA interference (RNAi) agents through certain structural modifications. The issued claims not only cover enhancing the efficacy of silencing gene expression using short interfering RNA (siRNA) but also include specific claims directed to micro RNA (miRNA), pre-miRNA, and short hairpin RNA (shRNA).

Silence owns exclusive licenses to three Zamore patent families from the University of Massachusetts Medical School, where Zamore is the co-director of the RNA Therapeutics Institute. These patent families disclose various efficacy-enhancing methods and structural elements for RNAi therapeutics, informally known as the "Zamore design rules" and based on Dr. Zamore's work atUMass. The company expects additional U.S. patent issuances related to this Zamore intellectual property portfolio in the coming months.

"Today's patent issuance continues to highlight the powerful synergies created by the combined assets of Silence and Intradigm. In this case, the exclusive licenses originally owned by Intradigm to the Zamore patent families have provided Silence with valuable structural modification technology that will contribute to further strengthening and expanding the company's comprehensive RNAi therapeutic platform," stated Philip Haworth, Ph.D., chief executive officer of Silence Therapeutics. "There is a growing consensus within the industry regarding the important role of optimized siRNA structure for developing more potent next generation RNAi therapeutics. With exclusive access to the industry leading technology in this area, Silence continues to position itself as the partner-of-choice for pharmaceutical companies with interest in the RNAi space."

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