My watch list
my.bionity.com  
Login  

Bacteria block transmission of Zika and Dengue viruses

29-Jan-2018

Wikimages; pixabay.com; CC0

Symbolic picture

Scientists at the University of Glasgow have found a bacterial strain which blocks dengue and Zika virus transmission from mosquitoes. 

In the new study scientists show that a novel strain of the inherited bacteria Wolbachia strongly blocks transmission of dengue and Zika virus among infected mosquitoes, offering a potential alternative to strains already being tested as virus control tools.

Scientists from the University of Glasgow’s MRC Centre for Virus Research (CVR) have carried out the research in the mosquito species Aedes aegypti, which spreads a number of dangerous human viruses, including dengue, Zika, and Chikungunya.

Previous research has shown that transmission of these viruses among mosquitoes is inhibited if the flies are deliberately infected with one strain of Wolbachia bacteria, and several countries are testing whether infecting local mosquito populations with Wolbachia could lower rates of viral disease in humans.

Now University of Glasgow CVR scientists have shown that a novel strain ‘wAu’ is even more effective for virus transmission blocking than strains currently being used, particularly in hot, tropical climates where there is high prevalence of these diseases. 

Several Wolbachia strains have already been tested in the field, but there is evidence to suggest that some strains may not block transmission very effectively or may not be inherited efficiently at high ambient temperatures. In the new study, the research team performed laboratory experiments to test the potential promise of alternative Wolbachia strains.

The researchers introduced four Wolbachia strains into Aedes aegypti mosquitoes, which do not naturally carry these arthropod-infecting bacteria. Two of the strains, wMel and wAlbB had already been evaluated in prior studies, and the scientists wanted to compare their effects with those of two novel strains, wAu and wAlbA.

The analysis revealed particularly promising results for strain wAu. After feeding on blood infected with dengue or Zika virus, mosquitoes infected with wAu had lower levels of viral RNA in their body tissue than did mosquitoes infected with the other strains. wAu also showed very high rates of inheritance, including under high-temperature conditions.

Quote from Professor Steven Sinkins: “The Wolbachia transmission blocking strategy shows great promise for the control of mosquito-borne viruses, and is now starting to be deployed on a large scale in a number of tropical countries. Our results with the wAu strain showed by far the effective transmission blocking for all the viruses we tested, and it provides an exciting new option to explore for disease control programmes".

Future research could explore strategies to maximize the effectiveness of wAu in the field, such as combining it with a second strain to help it spread throughout local mosquito populations.

Prof Sinkins holds a Global Challenges Research Fund (GCRF) grant, which is jointly awarded by the Biotechnology and Biological Sciences- and Medical Research Councils (BBSRC and MRC) . With the funding, he will lead a global network studying vector-borne diseases, such as malaria, Dengue and Zika. The goal is to reduce and block the transmission of pathogens by releasing specific insect disease vectors. Wolbachia, for example, is already starting to be deployed in several countries.

Dr Jonathan Pearce, Head of Infections and Immunity at the MRC, said: “This is incredibly relevant research with implications that can be applied to pressing issues on the ground in many parts of the world. These findings may be key to uncovering a new tool in the fight against the spread of mosquito-borne diseases.

“Meanwhile, the international network is pulling together experts from a wide range of scientific disciplines to exchange knowledge and brainstorm promising new ways to target vector-borne diseases.”

Facts, background information, dossiers
  • Zika virus
  • pathogens
More about University of Glasgow
  • News

    How superbugs rapidly evolve

    A scientific breakthrough has revealed a new way that bacteria evolves, thought to be at least 1,000 times more efficient than any currently known mechanism. The insights will help scientists to better understand how superbugs can rapidly evolve and become increasingly antibiotic resistant. ... more

    Genetic link discovered between circadian rhythms and mood disorders

    Circadian rhythms are regular 24-hour variations in behaviour and activity that control many aspects of our lives, from hormone levels to sleeping and eating habits. In the largest ever genetic study of circadian rest-activity cycles in humans, scientists at the University of Glasgow have i ... more

    Why some kidney transplants don’t work

    Scientists have discovered a ‘molecular signature’ for the allostatic load -- or ‘wear and tear’ of kidneys – which could help clinicians understand why some kidney transplants don’t work as well as expected. The University of Glasgow-led research, published today in Aging Cell and based on ... more

  • Universities

    University of Glasgow

    more

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE