Mysthera Therapeutics Launches to Develop First-in-Class Autoimmune Disease Therapies

Seed Capital from Forty51 Ventures to Advance Pipeline of Pan-PIM Kinase Inhibitors

28-Aug-2023 - Mysthera Therapeutics AG, a company developing first-in-class, oral therapeutics to treat complex autoimmune diseases, launched with $3.5 million seed capital from founding investor Forty51 Ventures. The capital will be used to advance its portfolio of pre-clinical stage, pan-PIM kinase ...

Genetic program protects neurons from degeneration

Study finds genes in fruit flies that are presumed to have a similar function in humans

17-Aug-2021 - Researchers at the University of Bonn have identified a previously unknown genetic program in the fruit fly. The genetic material involved controls the development of the neurons while also protecting them from degeneration. They have hardly changed in the course of evolution over hundreds of ...

Antibiotics: New substances break bacterial resistance

13-Nov-2019 - Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a new, promising class of active ingredients against resistant bacteria. In initial tests in cell cultures and insects, the substances were at least as effective as common antibiotics. The new compounds target a ...

'Druggable' cancer target found in pathway regulating organ size

Finding caps more than a decade of research on 'Hippo' pathway

21-Nov-2018 - It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer. It's further known that a major player in this pathway, YAP, drives many types of tumors. Now, researchers at Boston Children's ...

Newly discovered enzyme is 'firing pin' for plant immunity

19-Sep-2018 - Just like humans, plants have an immune system that helps them fight off infections. Plant immunity has some important differences: they don't make antibodies and can't fight off the same bug more quickly months or years later. However, plant cells can identify pathogens and react to them, often ...

Enzyme's movement may be key to new cancer drugs

17-May-2018 - Revealing all the steps required to activate an enzyme called a protein kinase may identify new ways to target cancer, according to new University of Arizona-led research. Not only must the kinase have all needed parts in place, the enzyme must move in the correct manner and at the correct speed ...

New insights into how your brain keeps its balance

23-Jan-2018 - As with all things in life, healthy brain function depends on a balance of forces. We think of our brains as active - moving a leg and saying a word are all "active" events. But it is just as important for our brains to be able to stop these actions -to stop our leg, and to stop our speech. But ...

New breast cancer drug defeats the Ras genes notorious for causing many types of cancer

13-Oct-2017 - Blocking the function of the Ras oncogenes is considered by many scientists to be the "holy grail" of cancer therapeutics because mutations in these genes drive the growth of so many different types of cancers. The three Ras genes found in humans -- H-Ras, K-Ras and N-Ras --were among the first ...

The fork in the road to DNA repair

13-Jul-2017 - The human body consists of trillions of cells, and within each are billions of DNA molecules. Strict maintenance of the molecules is essential to maintain a healthy cell and thus a healthy body. This maintenance is challenged by the daily bombardment of chemicals, UV light, radical oxgen and ...

New hope in the fight against superbugs

05-May-2017 - Antibiotic resistance is a growing global health threat. So much so that a 2014 study commissioned by the Prime Minister of the United Kingdom predicted that, if the problem is left unchecked, in less than 35 years more people will die from antibiotic resistant superbugs than from cancer. It is ...