Kinases

Companies Kinases

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

News Kinases

• 'Druggable' cancer target found in pathway regulating organ size
  

  It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer. It's further known that a major player in this pathway, YAP, drives many types of tumors. Now, researchers at Boston Children's Hospi more

• Newly discovered enzyme is 'firing pin' for plant immunity
  

  Just like humans, plants have an immune system that helps them fight off infections. Plant immunity has some important differences: they don't make antibodies and can't fight off the same bug more quickly months or years later. However, plant cells can identify pathogens and react to them, often by more

• Enzyme's movement may be key to new cancer drugs
  

  Revealing all the steps required to activate an enzyme called a protein kinase may identify new ways to target cancer, according to new University of Arizona-led research. Not only must the kinase have all needed parts in place, the enzyme must move in the correct manner and at the correct speed to more

White papers Kinases

• Dynamics of Kinases Involved in Cell Growth Using the xCELLigence System
  

  Studies investigating endogenous cellular regulatory mechanisms have substantially pushed the application of high-throughput screens. RNA interference has developed into an extremely powerful tool for mediating the loss-of-function of specific mRNA m more

Publications Kinases

• Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes

  by Kaitlyn L. Norman, Christian A. Shively, Amberlene J. De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J. Cullen, Anuj Kumar Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required for more

• Crosstalk between the serine/threonine kinase StkP and the response regulator ComE controls the stress response and intracellular survival of Streptococcus pneumoniae

  by Germán E. Piñas, Nicolás M. Reinoso-Vizcaino, Nubia Y. Yandar Barahona, Paulo R. Cortes, Rosario Duran, Chandan Badapanda, Ankita Rathore, Dario R. Bichara, Melina B. Cian, Nadia B. Olivero, Daniel R. Perez, José Echenique Streptococcus pneumoniae is an opportunistic human bacterial pathogen t more

• Histone depletion prevents telomere fusions in pre-senescent cells

  by Marta Barrientos-Moreno, Marina Murillo-Pineda, Ana M. Muñoz-Cabello, Félix Prado Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome during more