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• Genetic program protects neurons from degeneration
  

  Researchers at the University of Bonn have identified a previously unknown genetic program in the fruit fly. The genetic material involved controls the development of the neurons while also protecting them from degeneration. They have hardly changed in the course of evolution over hundreds of millio more

• Antibiotics: New substances break bacterial resistance
  

  Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a new, promising class of active ingredients against resistant bacteria. In initial tests in cell cultures and insects, the substances were at least as effective as common antibiotics. The new compounds target a specia more

• 'Druggable' cancer target found in pathway regulating organ size
  

  It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer. It's further known that a major player in this pathway, YAP, drives many types of tumors. Now, researchers at Boston Children's Hospi more

Publications Kinases

• Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes

  by Kaitlyn L. Norman, Christian A. Shively, Amberlene J. De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J. Cullen, Anuj Kumar Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required for more

• Crosstalk between the serine/threonine kinase StkP and the response regulator ComE controls the stress response and intracellular survival of Streptococcus pneumoniae

  by Germán E. Piñas, Nicolás M. Reinoso-Vizcaino, Nubia Y. Yandar Barahona, Paulo R. Cortes, Rosario Duran, Chandan Badapanda, Ankita Rathore, Dario R. Bichara, Melina B. Cian, Nadia B. Olivero, Daniel R. Perez, José Echenique Streptococcus pneumoniae is an opportunistic human bacterial pathogen t more

• Histone depletion prevents telomere fusions in pre-senescent cells

  by Marta Barrientos-Moreno, Marina Murillo-Pineda, Ana M. Muñoz-Cabello, Félix Prado Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome during more