My watch list  

T helper 17 cell

T helper 17 cells (Th17) are a subset of interleukin 17-producing T helper cells. They are considered developmentally distinct from Th1 and Th2 cells and are thought to play a key role in autoimmune disease.[1][2]

Additional recommended knowledge


Activation of precursor T helper cells in the presence of TGF-beta and IL-6 is thought to drive differentiation of Th17 cells. Aside from cytokine environment, it is unclear whether any other elements of the initial activation of Th17 cells differ from those of other T helper cells. It has been suggested that IL-23 is involved in the expansion of established Th17 populations. IL-21, a cytokine produced by Th17 cells themselves, has also been shown to initiate an alternative route for the activation of Th17 populations.[3] Both Interferon gamma and IL-4, the main stimulators of Th1 and Th2 differentiation respectively, have been shown to negatively regulate Th17 differentiation.


On initial characterisation, Th17 cells were broadly implicated in autoimmune disease and auto-specific Th17 were shown to be highly pathogenic. A more natural role for Th17 cells is suggested by studies which have demonstrated preferential induction of IL-17 in cases of host infection with various bacterial and fungal species. Th17 primarily produce two main members of the IL-17 family; IL-17A and IL-17F which are involved in the recruitment, activation and migration of neutrophils.


  1. ^ Harrington, LE; RD Hatton & PR Mangan et al. (2005), " ", Nature Immunology 6 (11): 1023-32, PMID 16200070
  2. ^ Stockinger B, Veldhoen M (2007). "Differentiation and function of Th17 T cells". Curr. Opin. Immunol. 19 (3): 281–6. PMID 17433650.
  3. ^ Korn, T; E Bettelli & W Gao et al. (2007), " ", Nature 448: 484-488, PMID 17766098

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "T_helper_17_cell". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE