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Granulocyte



    Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm.[1] They are also called polymorphonuclear leukocytes (PMN or PML) because of the varying shapes of the nucleus, which is usually lobed into three segments. In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes,[2] the most abundant of the granulocytes. Granulocytes or PMN are released from the bone marrow by the regulatory complement proteins.

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Contents

Classification

There are three types of granulocytes, distinguished by their appearance under Wright's stain:

Their names are derived from their staining characteristics; for example, the most abundant granulocyte is the neutrophil granulocyte, which has neutrally-staining cytoplasmic granules.

Other white blood cells which are not granulocytes ("agranulocytes") are mainly lymphocytes and monocytes.

Toxic materials produced or released

Examples of toxic produced or released by degranulation by granulocytes on the ingestion of microorganism includes:

Pathology

Granulocytopenia is an abnormally low concentration of granulocytes in the blood. This condition reduces the body's resistance to many infections. Closely-related terms include agranulocytosis and neutropenia.

A granuloma is a tumor containing granulocytes, and a "granulomatosis" is a necrotizing granuloma.

There is usually a granulocyte chemotactic defect in individuals who suffer from insulin dependent diabetes mellitus.

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See also

References

  1. ^ granulocyte at eMedicine Dictionary
  2. ^ polymorphonuclear+leukocyte at eMedicine Dictionary
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Granulocyte". A list of authors is available in Wikipedia.
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