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L-gulonolactone oxidase (EC 22.214.171.124) is an enzyme that catalyzes the reaction of D-glucuronolactone (also known as L-gulono-1,4-lactone) with oxygen to L-xylo-hex-3-ulonolactone and hydrogen peroxide. It uses FAD as a cofactor.
Additional recommended knowledge
The CAS number for this enzyme is 9028-78-8
Gulonolactone oxidase deficiency
The non-functional GULOP was mapped to human chromosome 8p21 that corresponds to an evolutionarily conserved segment on either porcine chromosome 4 (SSC4) or 14 (SSC14). GULO produces ascorbic acid, which is often called "vitamin C".
Gulonolactone oxidase deficiency is called "hypoascorbemia" and is described by OMIM (Online Mendelian Inheritance in Man) as "a public inborn error of metabolism", as it affects all humans. There exists a wide discrepancy between the amounts of ascorbic acid other primates consume and what is recommended as "reference intakes" for humans.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "L-gulonolactone_oxidase". A list of authors is available in Wikipedia.|