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Amorolfine



Amorolfine
Systematic (IUPAC) name
(2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4-
(2-methylbutan-2-yl)phenyl]propyl]morpholine
Identifiers
CAS number 60719-84-8
ATC code D01AE16
PubChem 54260
Chemical data
Formula C21H35N 
Mol. mass 317.509 g/mol
Pharmacokinetic data
Bioavailability  ?
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Therapeutic considerations
Pregnancy cat.

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Legal status
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Amorolfine (or amorolfin), is an antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Additional recommended knowledge

Marketed as Curanail, Loceryl, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.

Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Amorolfine". A list of authors is available in Wikipedia.
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