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Benzimidazole



Benzimidazole

Systematic (IUPAC) name
1H-benzoimidazole
Synonyms
BI
Identifiers
PubChem         5798
Chemical data
Formula C7H6N2 
Molar mass 118.136
Complete data

Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. The most prominent benzimidazole compound in nature is N-ribosyl-dimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. [1]

Additional recommended knowledge

It is produced commercially as an parasiticide. The usual synthesis involves condensation of trimethylorthoformate and o-phenylenediamine:

C6H4(NH2)2 + HC(OCH3)3 → C6H4N(NH)CH + 3 CH3OH

Benzimidazole, in an extension of the well-elaborated imidazole system, has been used as carbon skeletons for N-heterocyclic carbenes. The NHCs are usually used as ligands for transition metal complexes. They are often prepared by deprotonating an N,N'-disubstituted benzimidazolium salt at the 2-position with a base.[2][3]

See also

  • Albendazole, a common use anthelmintic.
  • Indole, an analog with CH in place of nitrogen in position 3.
  • Purine, an analog with two additional nitrogen atoms in the six-membered ring.
  • Simple aromatic rings
  • Triclabendazole, most common drug against liver flukes

References

  1. ^ H. A. Barker, R. D. Smyth, H. Weissbach, J. I. Toohey, J. N. Ladd, and B. E. Volcani (1960). "Isolation and Properties of Crystalline Cobamide Coenzymes Containing Benzimidazole or 5,6-Dimethylbenzimidazole". Journal of Biological Chemistry 235 (2): 480 - 488.
  2. ^ R. Jackstell, A. Frisch, M. Beller, D. Rottger, M. Malaun and B. Bildstein (2002). "Efficient telomerization of 1,3-butadiene with alcohols in the presence of in situ generated palladium(0)carbene complexes". Journal of Molecular Catalysis A: Chemical 185 (1-2): 105-112. doi:10.1016/S1381-1169(02)00068-7.
  3. ^ H. V. Huynh, J. H. H. Ho, T. C. Neo and L. L. Koh (2005). "Solvent-controlled selective synthesis of a trans-configured benzimidazoline-2-ylidene palladium(II) complex and investigations of its Heck-type catalytic activity". Journal of Organometallic Chemistry 690 (16): 3854-3860. doi:10.1016/j.jorganchem.2005.04.053.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Benzimidazole". A list of authors is available in Wikipedia.
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