Brain Diseases

The recording of images of the human brain and its therapy in neurodegenerative diseases is still a major challenge in current medical research. The so-called blood-brain barrier, a kind of filter system of the body between the blood system and the central nervous system, constrains the supply of dr more

University of Bath scientists have developed a better understanding of a key protein associated with brain diseases including ALS (motor neurone disease) and dementia by studying how it enters central nervous system cells. Researchers from the Department of Biology & Biochemistry studied how angioge more

The programme controls how and when brain genes are expressed at different times in a person's life to perform a range of functions, the study found. Experts say the timing is so precise that they can tell the age of a person by looking at the genes that are expressed in a sample of brain tissue. Sc more

The roles of low-voltage-activated (T-type) calcium channels in brain diseases have been studied extensively. Less is known regarding the involvement of T-type channels in cognition and behavior. Sensory integration (SI) is a cognitive process whereby the brain uses unimodal or multimodal sensory f more

Recent advances in genomics have revealed that many polygenetic diseases are caused by complex combinations of many common variants with individually small effects. Thus, building informative disease models requires the interrogation of many patient-derived genetic backgrounds in a disease-relevant more

Frontotemporal lobar degeneration (FTLD) represents a group of neurodegenerative brain diseases with highly heterogeneous clinical, neuropathological and genetic characteristics. This high degree of heterogeneity results from the presence of several different underlying molecular disease processes; more