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Diethyltryptamine



Diethyltryptamine
Systematic (IUPAC) name
N,N-diethyl-2-(1H-indol-3-yl)ethanamine
Identifiers
CAS number	7558-72-7
ATC code	?
PubChem	6090
Chemical data
Formula	C₁₄H₂₀N₂
Mol. mass	216.32 g/mol
SMILES	search in eMolecules, PubChem
Physical data
Melt. point	169–171 °C (336–340 °F)
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Class A(UK) Schedule I(US)
Routes	?

DET (N,N-diethyltryptamine) or T-9 is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100 mg without the aid of MAO inhibitors lasting about 2-4 hours.

1 Pharmacology
2 Biochemistry
3 Psychosis model
4 See also
5 References

Pharmacology

The mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics.^[1]

Biochemistry

Though DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.^[2]

Psychosis model

Early studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic properties.^[3] Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders as schizophrenia, or psychosis.^[4] With the progression of science and pharmacological understanding this belief remains dismissed by most researchers.

References

^ BEHAVIORAL EFFECTS OF N, N-DIETHYLTRYPTAMINE: ABSENCE OF ANTAGONISM BY XYLAMIDINE TOSYLATE -- WINTER 169 (1): 7 -- Journal of Pharmacology And Experimental Therapeutics. Retrieved on 2008-01-03.
^ Biotransformation of tryptamine derivatives in myc...[J Basic Microbiol. 1989 - PubMed Result]. Retrieved on 2008-01-03.
^ [http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2633 PSILOCYBIN AND DIETHYLTRYPTAMINE: TWO TRYPTAMINE HALLUCINOGENS]. Retrieved on 2008-01-03.
^ Effects of LSD-25, N,N-Dimethyltryptamine (DMT), and N,N-Diethyltryptamine (DET) on the Photic Evoked Responses in the unanesthetized Rabbit. Retrieved on 2008-01-03.

v • d • e

Psychedelic tryptamines

α,N,N-TMT • 2,N,N-TMT • 5,N,N-TMT • 4-Acetoxy-DMT • 4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-HO-5-MeO-DMT • α-ET • α-MT • Baeocystin • Bufotenin • DBT • DET • DIPT • DMT • DPT • EiPT • PiPT • Ethocin • Ethocybin • Iprocin • 4-HO-MET • 4-HO-MiPT • MET • MIPT • 5-Me-MIPT • 5-MeO-α-ET • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MET • 5-MeO-MIPT • 5-MeO-α,N,N-TMT • 5-MeO-2,N,N-TMT • Miprocin • Norbaeocystin • Psilocin • Psilocybin

v • d • e

Drugs from TiHKAL

AL-LAD • DBT • DET • DiPT • 5-MeO-α-MT • DMT • 2,α-DMT • α,N-DMT • DPT • EiPT • α-ET • ETH-LAD • Harmaline • Harmine • 4-HO-DBT • 4-HO-DET • 4-HO-DiPT • 4-HO-DMT • 5-HO-DMT • 4-HO-DPT • 4-HO-MET • 4-HO-MiPT • 4-HO-MPT • 4-HO-pyr-T • Ibogaine • LSD • MBT • 4,5-MDO-DiPT • 5,6-MDO-DiPT • 4,5-MDO-DMT • 5,6-MDO-DMT • 5,6-MDO-MiPT • 2-Me-DET • 2-Me-DMT • Melatonin • 5-MeO-DET • 5-MeO-DiPT • 5-MeO-DMT • 4-MeO-MiPT • 5-MeO-MiPT • 5,6-MeO-MiPT • 5-MeO-NMT • 5-MeO-pyr-T • 6-MeO-THH • 5-MeO-TMT • 5-MeS-DMT • MiPT • α-MT • NET • NMT • PRO-LAD • pyr-T • Tryptamine • Tetrahydroharmine • α,N,O-TMS

v • d • e

Tryptamines

4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-HO-DIPT • 5-Bromo-DMT • 5-Fluoro-α-MT • 5-MeO-α-ET • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MIPT • α-ET • α-MT • Baeocystin • Bufotenin • DET • DiPT • DMT • DPT • Ethocybin • EiPT • Ethocin • Ibogaine • Iprocin • MET • MiPT • Miprocin • Melatonin • NMT • Norbaeocystin • Normelatonin • PiPT • Psilocin • Psilocybin • Rizatriptan • Serotonin • Sumatriptan • Tryptamine • Tryptophan