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18 Current white paper about the topic expressionrss
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On the RealTime ready Configurator, we offer function tested human, mouse, and rat qPCR assays for gene expression quantification based on the unique Universal ProbeLibrary technology (UPL). The Universal ProbeLibrary is a set of short hydrolysis pro
The gene and transcript annotational content of the RealTime ready Configurator offers a combined view of three of the main gene annotation authorities. The positional information of the lab-tested RealTime ready assays regarding transcript or exon c
Each antibody-antigen interaction has unique characteristics. A protocol giving good results for one antibody-antigen pair might found to be unsatisfactory for a second antibody even on the same sample. The interaction of antisera with protein epitop
Smart Solutions for large Molecules
As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace
Although congenital heart malformations are the most common birth defects in humans, the underlying pathomechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defect
Macaques provide essential preclinical models for infectious disease, vaccine, biodefense, and transplantation research. Unfortunately, they also have the most complex MHC genetics of any primate species described to date, and existing methods for MH
The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in ce
Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to
Gene expression profiling of the human genome on the LightCycler® 480 System has never been so easy.
RealTime ready qPCR Assays redefine real-time qPCR because each assay is function-tested in PCR and qualified under strict criteria to assure superior performance. The RealTime ready Assays are based on the well-known Universal ProbeLibrary (UPL) tec
To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million fe