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16 Current white paper about the topic diseases

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Novel aggregation-specific fluorogen monitors prefibrillar protein aggregation by fluorescence polarisation (FP)

17-Oct-2018

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative

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Orphan Drugs – An Alternative to the declining Blockbuster Model?

20-Jan-2012

Up until the new millennium, the pharmaceutical industry grew stronger by 11%. However, the blockbuster model is increasingly at risk and the declining growth rates in the industry require a search for new strategies. In this context, orphan drugs ar

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Clinical Biomarkers: Novel Tools for Pharmacodynamic Applications

14-Oct-2011

Biomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diag

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Characterizing Biotherapeutics with HPLC

Smart Solutions for large Molecules

24-Nov-2010

As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace

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Sniffing Out the Secrets of Social Behavior

Prof. Marc Spehr on the New Understanding of Olfactory Neurosensorics

20-Sep-2010

In his novel "Perfume - the Story of a Murderer", Patrick Süskind managed to put the power of odors into words better than anyone before him

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Nobel Prize for Solving the End-Replication Problem

27-Jan-2010

The Nobel Assembly awarded this year's Nobel Prize in Medicine to Elizabeth H. Blackburn, Jack W. Szostak, and Carol W. Greider for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. With their ingenious genetic re

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High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System

25-Jan-2010

Although congenital heart malformations are the most common birth defects in humans, the underlying patho­mechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defect

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Major Histocompatibility Complex Genotyping with Massively Parallel Pyrosequencing

04-Jan-2010

Macaques provide essential preclinical models for infectious disease, vaccine, biodefense, and transplantation research. Unfortunately, they also have the most complex MHC genetics of any primate species described to date, and existing methods for MH

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Amplicon Sequencing with the GS FLX Titanium Series: High Sensitivity Targeted Resequencing

30-Nov-2009

Amplicon sequencing with the Genome Sequencer FLX System has already enabled a wide variety of scientific discoveries, particularly in clinical research. The introduction of the GS FLX Titanium Chemistry and the release of the associated amplicon seq

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Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

30-Nov-2009

To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million fe

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