Dominic Roberts, Cristian Cojocariu, Kayleigh Arthur, Jonathan Lawson

Learn how breath analysis can detect disease and cancer in its early stage

Breath contains over 1,000 volatile organic compounds (VOCs), as well as microscopic aerosol particles that provide a rich source of biological information

Unlike blood and tissue sampling, breath offers a non-invasive and pain free way to monitor human biology and enable the critical early detection of disease and optimization of treat-ments through precision medicine.
Compared to genomics and other -omics approaches, studying breath volatile organic compounds (VOCs), socalled breathomics, reveals the current health status of cells, tissues and the microbiome. Breathomics goes beyond probability and predispositions, to reveal what is happening now. Many breath biomarkers are associated with metabolic or disease processes in the body. The ability to accurately collect and analyze them has applications in early detection, screening, prognosis and precision medicine including for patient stratification in therapy selection and treatment monitoring.

Breath analysis workflow starts with collection of exhaled Breath using the ReCIVA™ Breath Sampler (Owlstone Medical), which ensures reliable and reproducible sample collection. The volatile organic compounds from the exhaled breath are captured on Breath Biopsy™ cartridges (Owlstone Medical), which are then analyzed using thermal desorption coupled to the Thermo Scientific™ Q Exactive™ GC Orbitrap™ GC-MS/MS system, to provide a highresolution volatile organics profile of the breath sample for further evaluation.

For research use only. Not for diagnostic procedures.

Facts, background information, dossiers
  • breath analysis
  • breathomics
  • breath biomarkers
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