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Octet SF3
Surface Plasmon Resonance (SPR) using Single Dynamic Injections for Kinetics and Affinities
Time and cost savings – No need to make multiple concentration dilutions
High throughput - Automated capacity of up to 768 samples per run
Versatility - Perform competition screens in addition to affinity screens
Curvature is Key - Adding a ‘Third Dimension’ to the Binding Curve
One of the most common applications of surface plasmon resonance (SPR) is identification and characterisation of new drugs in the pharmaceutical industry. The Octet SF3 SPR instrument brings you in "OneStep" to the accurate characterisation of protein-protein interactions and the binding of low molecular weight compounds to protein structures.
Unlike the traditional approach of multi-cycle kinetics based on a dilution series in a matched concentration range, with the patented OneStep single gradient injection, the binding curve is generated from the change in reaction over time simultaneously with the change in concentration over time. This leads to much more information and allows the calculation of the complete binding kinetics with only one concentration, which always falls within the measurable concentration range due to the dilution process. Imagine getting target structures, binding kinetics and aggregation data from your primary screen with a single injection.
Increase the efficiency and quality of fragment-based drug screenings with OneStep.
1
High-throughput Surface Plasmon Resonance (SPR) for faster hit identification with unique patented injection modes.
2
The SPR solution to be powered and prepared for whatever challenge in research and development of drug discovery.
3
Study interactions at physiological temperatures to rapidly assess binding kinetics and affinity of drug candidates and biotherapeutics.
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Octet SF3
Surface Plasmon Resonance (SPR) using Single Dynamic Injections for Kinetics and Affinities
