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ÄKTA Protein Purification Systems – Easy to Use Benchtop Systems to Accelerate Daily Routines

Designed for purification of biomolecules, providing speed, performance, and flexibility in research and process development more

News Peptides

• Chemistry-for-Healthcare Start-up secures seed investment
  

  Belyntic, a Berlin-based chemistry-for-healthcare startup and developer of the Peptide Easy Clean (PEC) purification technology, has completed its seed financing round amounting to €1.3 million. The funding is led by the Investitionsbank Berlin (IBB), with the High-Tech Gründerfonds (HTGF) also clim more

• Stem cells moonlight to protect the stomach from bacterial invaders
  

  Our mucosal surfaces are constantly exposed to numerous bacterial species, some of which can induce DNA damage in host cells. Normally this remains inconsequential, as the rapid turnover of the mucosa means damaged cells are shed within days. However, if the long-lived stem cells that continually gi more

• First use of vasoprotective antibody in cardiogenic shock
  

  Scientists at the German Centre for Cardiovascular Research (DZHK) have started a study to find out whether a monoclonal antibody restoring vascular integrity is safe and has positive effects on organ functions of patients with cardiogenic shock. The multicenter trial is sponsored by the University more

Videos Peptides

ÄKTA Protein Purification Systems – Easy to Use Benchtop Systems to Accelerate Daily Routines

ÄKTA™ lab-scale protein purification systems are designed for purification of biomolecules, providing speed, performance, and flexibility in research and process development. ÄKTA systems use intelligent UNICORN™ system control software to combine simplicity with power in protein purification from y more

White papers Peptides

• Enzyme Kinetic Measurements for a Combinatorial Library of Inhibitors of Pseudomonas Elastase
  

  Pseudomonas elastase (LasB) is a key drug target in various chronic and intractable infections. A library of 160 potential, in-house synthesised, elastase inhibitors were screened using a fluorescence assay with the internally quenched substra more

• Method for Producing reduced Glycans and Glycan-arrays
  

  The invention presented here provides an improved method for the preparation of multiple types of glycans and their usage more

• Characterizing Biotherapeutics with HPLC
  

  As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace more

Infographics Peptides

A Brief Overview of Classes of Antibiotics

When we’re suffering from a bacterial infection, a trip to the doctors to be prescribed antibiotics is commonplace. However, there are a wide range of antibiotics available, and they vary both in their usage and their mechanism of action. This graphic summarises the major classes, and also gives a b more

The Chemistry of Spider Venom

Spider venoms can be grouped into two broad categories: necrotic, and neurotoxic. Necrotic, or cytotoxic venoms, are those which cause cell and tissue damage after envenomation. This can lead to the appearance of inflammation, lesions, and blisters. Neurotoxic venoms, on the other hand, exert their more

Harnessing evolution to produce new enzymes and antibodies

The last of the 2018 Science Nobel Prizes is awarded, and it was finally the turn of chemistry. The 2018 Nobel Prize in Chemistry was awarded with one half to Frances H Arnold for her work on the directed evolution of enzymes, and with the other half jointly to George P Smith and Sir Gregory P Winte more

Publications Peptides

• Marine Drugs, Vol. 16, Pages 220: Cyanopeptolins with Trypsin and Chymotrypsin Inhibitory Activity from the Cyanobacterium Nostoc edaphicum CCNP1411

  Marine Drugs, Vol. 16, Pages 220: Cyanopeptolins with Trypsin and Chymotrypsin Inhibitory Activity from the Cyanobacterium Nostoc edaphicum CCNP1411 Marine Drugs doi: 10.3390/md16070220 Authors: Hanna Mazur-Marzec Anna Fidor Marta Cegłowska Ewa Wieczerzak Magdalena Kropidłowska Ma more

• Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens

  by Daniel Pletzer, Sarah C. Mansour, Robert E. W. Hancock With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly difficult to treat due to their adaptive multidrug-resistance and currently there are more

• Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking [Biochemistry]

  Beclin 1 is an essential autophagy protein. Through its coiled-coil domain, Beclin 1 recruits two modulators, Atg14L and UVRAG, to form Atg14L- or UVRAG-containing Beclin 1–Vps34 subcomplexes responsible for Vps34-dependent membrane trafficking processes including autophagy and endosomal trafficking more