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8 Current news about the topic proteasomesrss
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NovAliX, a drug discovery-focused Contract Research Organization (CRO) announces that it has signed a cooperation agreement with German-based ProteoPlex GmbH, a spin-off company of the Max-Planck-Institute for Biophysical Chemistry (MPIBPC). Under the terms of the agreement, NovAliX will ...
Altering the protein recycling complexes in human cells, including cancer cells, allows the cells to resist treatment with a class of drugs known as proteasome inhibitors, according to Whitehead Institute scientists. "This is why some cancers can be so difficult to treat with chemotherapy, ...
Scientists estimate that our brain consists of about ten to one hundred billions of nerve cells. In order to fulfill their respective tasks as long as possible, these cells have to constantly control their internal proteins with regard to quality and functionality. Otherwise the proteins might ...
New mechanism for inhibition of the immunoproteasome revealed
Multiple sclerosis, type 1 diabetes and lupus have one thing in common: They are all autoimmune diseases in which the immune cells can no longer differentiate between friend or foe and thus attack the body’s own tissue. Here, the immunoproteasome, which supplies the immune system with information ...
Findings further understanding of how pathogen survives
Scientists looking for new ways to fight tuberculosis (TB) have their sights set on a structure essential to the bacterium's survival. Disabling this structure could kill the microbes in the infected host and thwart TB infections. In a study in EMBO Journal scientists from the U.S. Department of ...
Cancer remains a deadly threat despite the best efforts of science. New hopes were raised a few years ago with the discovery that the uncontrolled growth of cancer cells could be thwarted by blocking the action of proteasomes. Biochemists at the Technische Universitaet Muenchen (TUM) have ...
Researchers at Wake Forest University School of Medicine are the first to show that the location of protein-destroying "machines" in nerve cells in the brain may play an important role in how memories are formed - a finding with potential implications for treating Alzheimer's and other brain ...
Cambridge, MA, December 10, 2001 - Millennium Pharmaceuticals, Inc. announced today preliminary findings of an ongoing phase II clinical trial of its investigational drug LDP-341 (formerly known as PS-341) in patients with multiple myeloma who have failed to respond to other treatments. The study ...