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9 Current news about the topic proteasomes


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Development of novel proteasome inhibitors for treating cancer, inflammatory and autoimmune disorders

Launch of Start-up QLi5 Therapeutics


The Lead Discovery Center GmbH (LDC) and the South Korean drug development specialist Qurient have founded QLi5 Therapeutics GmbH, together with their partners, the Max Planck Society (MPG) and Nobel laureate Prof. Huber, emeritus director of the Max Planck Institute for Biochemistry. Dortmund ...


NovAliX enters into cooperation agreement with Max-Planck spin-off


NovAliX, a drug discovery-focused Contract Research Organization (CRO) announces that it has signed a cooperation agreement with German-based ProteoPlex GmbH, a spin-off company of the Max-Planck-Institute for Biophysical Chemistry (MPIBPC). Under the terms of the agreement, NovAliX will ...


Cellular recycling complexes may hold key to chemotherapy resistance


Altering the protein recycling complexes in human cells, including cancer cells, allows the cells to resist treatment with a class of drugs known as proteasome inhibitors, according to Whitehead Institute scientists. "This is why some cancers can be so difficult to treat with chemotherapy, ...


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Live broadcast from inside the nerve cell


Scientists estimate that our brain consists of about ten to one hundred billions of nerve cells. In order to fulfill their respective tasks as long as possible, these cells have to constantly control their internal proteins with regard to quality and functionality. Otherwise the proteins might ...


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Spot on against autoimmune diseases and chronic inflammations

New mechanism for inhibition of the immunoproteasome revealed


Multiple sclerosis, type 1 diabetes and lupus have one thing in common: They are all autoimmune diseases in which the immune cells can no longer differentiate between friend or foe and thus attack the body’s own tissue. Here, the immunoproteasome, which supplies the immune system with information ...


New details of tuberculosis protein-cleaving machinery revealed

Findings further understanding of how pathogen survives


Scientists looking for new ways to fight tuberculosis (TB) have their sights set on a structure essential to the bacterium's survival. Disabling this structure could kill the microbes in the infected host and thwart TB infections. In a study in EMBO Journal scientists from the U.S. Department of ...


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Fine-tuning an anti-cancer drug


Cancer remains a deadly threat despite the best efforts of science. New hopes were raised a few years ago with the discovery that the uncontrolled growth of cancer cells could be thwarted by blocking the action of proteasomes. Biochemists at the Technische Universitaet Muenchen (TUM) have ...


Researchers Make New Finding about How Memory is Stored


Researchers at Wake Forest University School of Medicine are the first to show that the location of protein-destroying "machines" in nerve cells in the brain may play an important role in how memories are formed - a finding with potential implications for treating Alzheimer's and other brain ...


New Phase II Data on Millennium's Proteasome Inhibitor Holds Promise for Patients with Refractory Multiple Myeloma


Cambridge, MA, December 10, 2001 - Millennium Pharmaceuticals, Inc. announced today preliminary findings of an ongoing phase II clinical trial of its investigational drug LDP-341 (formerly known as PS-341) in patients with multiple myeloma who have failed to respond to other treatments. The study ...


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