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517 Current news about the topic immune system

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Hijacking in the immune system

The human cytomegalovirus reprograms cellular defence mechanisms

01-Mar-2024 - The human cytomegalovirus, HCMV for short, lies dormant unnoticed in the body of most people for their entire lives. In immunocompromised individuals, however, the virus can cause life-threatening infections. It infects dendritic cells, a specific type of cell in the immune system. Although the ...

cytomegalovirus dendritic cells human cytomegalovirus +6
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Immune system meets cancer: Checkpoint identified to fight solid tumors

Checkpoint PHDGH in tumor-associated macrophages influences immune response and tumor growth

29-Feb-2024 - A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the ...

artificial intelligence cancer immune cells +5
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Possible trigger for autoimmune diseases discovered

B cells teach T cells which targets must not be attacked

28-Feb-2024 - Immune cells must learn not to attack the body itself. A team of researchers from the Technical University of Munich (TUM) and the Ludwig Maximilian University of Munich (LMU) has discovered a previously unknown mechanism behind this: other immune cells, the B cells, contribute to the "training" ...

antiphospholipid syndrome autoimmune diseases B cells +7
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Revolutionary cell therapy: rebooting the immune system stops autoimmune diseases

Single infusion of CAR-T cells replaces immunosuppressive drugs

23-Feb-2024 - In March 2021, doctors at FAU treated a young woman with a severe autoimmune disease with chimeric antigen receptor (CAR) T cells for the first time in the world. Today, almost three years later, they have now been able to publish a pilot study in the New England Journal of Medicine and show that ...

autoimmune diseases B cells B-lymphocytes +6
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Shredding to plan – protein recycling for immune defense

“If we know how the proteasome generates immunopeptides, we can predict peptide splicing. In future, these predictions could, in turn, help develop novel vaccines against cancer or infectious diseases”

16-Feb-2024 - The waste system of living cells, the proteasome, not only shreds disused or damaged proteins. It also supports the immune system in recognizing virally infected or cancerous cells by producing protein fragments, so-called immunopeptides. In an international collaboration, researchers led by ...

cancer immune system immunopeptides +5
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Stress influences brain and psyche via immune system

This newly discovered connection could lead to new treatments for depression

12-Feb-2024 - Chronic stress affects the immune system and the brain. UZH researchers now show that a particular enzyme found in cells of the immune system enters the brain under stress. In mice, it causes them to withdraw and avoid social contact. This newly discovered connection between body and mind in ...

brain depressions immune cells +4
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Gene scissors repair defective immune cells

CRISPR-Cas9 can be used to repair hereditary genetic defects that lead to an excessive immune response, which can be fatal

06-Feb-2024 - Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease of the immune system. It usually affects infants and young children up to 18 months of age. The disease is severe and mortality is high. It is caused by various gene mutations that prevent cytotoxic T cells from functioning ...

cytotoxic T cells gene scissors hemophagocytic lymphohistiocytosis +2
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Calluna Pharma launches and announces EUR 75 million Series A financing to develop novel therapies for inflammatory and fibrotic diseases

Calluna Pharma has a pipeline of selective antibodies targeting immunological diseases

01-Feb-2024 - Oxitope Pharma (Oxitope) and Arxx Therapeutics (Arxx), companies with a shared goal of leveraging the innate immune system to discover and develop disease modulating therapies, announced their merger to form Calluna Pharma Inc. (Calluna). Calluna has raised EUR 75 million in a series A financing ...

asthma chronic renal disease fibrosis +7
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How the coronavirus defends itself against our immune system

Research team identifies "protective switches" in the protein of the SARS-CoV-2 virus

25-Jan-2024 - Over 700 million people were infected and almost seven million died, making SARS-CoV-2 the most devastating pandemic of the 21st century. Vaccines and medication against Covid-19 have been able to mitigate the course of the disease in many people and contain the pandemic. However, the danger of ...

coronaviruses Covid-19 cysteine +3
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Antibiotics highjack bacterial immunity

Molecular defense system protects bacteria from viruses and at the same time makes them susceptible to antibiotics

23-Jan-2024 - Bacteria have an immune system that protects them against viruses known as bacteriophages. A research team from the Universities of Tübingen and Würzburg has now shown how this immune system enhances the effect of specific antibiotics against the cholera pathogen Vibrio cholerae. The immune ...

antibiotics bacteria bacterial immune system +8