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59 Current news about the topic chromatin

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The recipe for making a fruit fly

Scientists use mass spectrometry to determine the absolute copy number of nuclear proteins and histone marks

21-Oct-2019

Currently, most if not all of the proteins that are required for constructing a multicellular organism are known. However, it is largely unclear how many copies of each protein species are present and needed to permit an animal to develop into a complete organism. Researchers at the Max Planck ...

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BAFfling cancer growth strategies: new targets for chromatin remodeling mutations identified

21-Aug-2019

More than one-fifth of all human cancers harbor mutations in one of the members of the BAF chromatin remodeling complex. Deep biochemical and epigenomic characterization of a cell line panel comprehensively representing all these mutations enabled researchers at the CeMM Research Center for ...

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Going fishing in the protein pond using histones as a bait – how do cells decide how to repair their DNA?

27-Feb-2019

When DNA in the cell nucleus gets damaged, our cells can resort to a variety of repair mechanisms. A recent study published in 'Nature Cell Biology', to which scientists from Helmholtz Zentrum München made major contributions, elucidates the molecular basis by which a cell makes the choice ...

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A new piece to the puzzle sheds light on how UHRF1 regulates gene activity

08-Nov-2018

Epigenetic changes often play an important role in cancer, because they cause the genetic material to be read incorrectly at certain locations. Genes that are especially critical are those that control the growth and death of cells. Scientists at Helmholtz Zentrum München have now discovered new ...

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Biologists unravel another mystery of what makes DNA go 'loopy'

Precise methods of DNA 'packing' may affect gene expression

19-Mar-2018

Scientists discovered another key to how DNA forms loops and wraps inside the cell nucleus -- a precise method of "packing" that may affect gene expression. The journal Science published the research by biologists at Emory University, showing that a process known as hemimethylation plays a role ...

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Genome architecture caught in motion

12-Oct-2017

Researchers at The Wistar Institute have uncovered new aspects of the three-dimensional organization of the genome, specifically how the genetic material is compacted and de-compacted in a timely fashion during the different phases of the cell cycle. "We are just starting to appreciate that the ...

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Repetitive elements shape embryonic chromatin landscape

30-Aug-2017

Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly insignificant. Together with colleagues from the USA, scientists from the Helmholtz Zentrum München have now shown that ...

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RNA: a vicious pathway to cancer?

16-Aug-2017

According to the current doctrine, cancer cells develop due to mutations in genomic DNA. But could it be also caused also by faulty RNA molecules? A number of clues are pointing to this surprising hypothesis. Rolf Marschalek from the Institute of Pharmaceutical Biology at Goethe University ...

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Cell senescence is regulated by innate DNA sensing

02-Aug-2017

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old". Understanding the causes and impact of ...

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New 3-D imaging reveals how human cell nucleus organizes DNA and chromatin of its genome

31-Jul-2017

Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA. A team of researchers at the University of California San Diego School of Medicine and the Salk Institute for Biological Studies describe development and application of new electron ...

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