New mechanism that leads to inflammation in rheumatoid arthritis discovered

03-Mar-2017 - New research findings suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients. Understanding the mechanisms of inflammation in rheumatoid arthritis is important for the design of new therapies for ...

Metabolic pathway that drives tumor growth in aggressive cancers

03-Mar-2017 - Mount Sinai researchers have discovered that a rheumatoid arthritis drug can block a metabolic pathway that occurs in tumors with a common cancer-causing gene mutation, offering a new possible therapy for aggressive cancers with few therapeutic options, according to a study to be published in ...

New class of materials could revolutionize biomedical, alternative energy industries

30-Jan-2017 - Polyhedral boranes, or clusters of boron atoms bound to hydrogen atoms, are transforming the biomedical industry. These manmade materials have become the basis for the creation of cancer therapies, enhanced drug delivery and new contrast agents needed for radioimaging and diagnosis. Now, a ...

Depression in Young People Affects the Stomach, Anxiety the Skin

28-Nov-2016 - Mental disorders and physical diseases frequently go hand in hand. For the first time, psychologists at the University of Basel and Ruhr University Bochum have identified temporal patterns in young people: arthritis and diseases of the digestive system are more common after depression, while ...

Built-in Protective Mechanism against Inflammations: Kiel scientists investigate immune cells

15-Aug-2016 - The protein Interleukin-6 (IL-6) can take on different functions in cells, depending on how it activates the cells. If it activates cells via the classical signalling path, it helps with the regeneration of tissue, and is indispensable for fighting bacterial infections. However, if it activates ...

Nanoscale Trojan horses treat inflammation

24-May-2016 - Nanosized Trojan horses created from a patient's own immune cells have successfully treated inflammation by overcoming the body's complex defense mechanisms, perhaps leading to broader applications for treating diseases characterized by inflammation, such as cancer and cardiovascular diseases. An ...

New Bone Chewing Role for B Cells in Rheumatoid Arthritis

18-Apr-2016 - University of Rochester Medical Center researchers have uncovered a new mechanism of bone erosion and a possible biomarker for rheumatoid arthritis (RA). The group is the first to demonstrate that immune cells, called B cells, contribute directly to the breakdown of bone in RA by producing a ...

Saturated fats 'jet lag' body clocks, triggering metabolic disorders

11-Apr-2016 - It makes sense that people who are trying to slim down would avoid fats. But as anyone who has unsuccessfully tried this approach to dieting knows, it's not quite that simple. New research from the Texas A&M Health Science Center and Texas A&M AgriLife parses out why saturated fats are "bad"--and ...

Compound in green tea found to block rheumatoid arthritis

18-Feb-2016 - Researchers at Washington State University in Spokane have identified a potential new approach to combating the joint pain, inflammation and tissue damage caused by rheumatoid arthritis. Rheumatoid arthritis is a debilitating autoimmune disorder that mostly affects the small joints of the hands ...

First etanercept biosimilar approved in the European Union

Biogen will manufacture and commercialize BENEPALI® in the EU

19-Jan-2016 - The joint venture between Biogen and Samsung BioLogics, Samsung Bioepis, has been granted European Commission (EC) approval for BENEPALI ® , an etanercept biosimilar referencing Enbrel ®. BENEPALI has been granted marketing authorization in the European Union (EU) for the treatment of adults with ...