Heptares generates new insight into caffeine's molecular pharmacology to drive design of next-generation CNS therapeutics

First 3-D X-ray Co-structures of Caffeine and other Xanthines Bound to G-Protein Coupled Receptor (GPCR) Published in the Journal Structure

05-Sep-2011 - The journal Structure has published data from researchers at Heptares Therapeutics elucidating the molecular pharmacology of caffeine and its interaction with G-protein coupled receptors (GPCRs). Caffeine is known to inhibit adenosine receptors, a subfamily of GPCRs widely expressed in the brain, ...

BGU researchers identify a gene for nearsightedness

05-Sep-2011 - A Ben-Gurion University of the Negev research group led by Prof. Ohad Birk has identified a gene that leads to nearsightedness. In an article appearing online in the American Journal of Human Genetics this Thursday, Birk and his team reveal that a mutation in LEPREL1 has been shown to cause ...

UF medicinal chemists modify sea bacteria byproduct for use as potential cancer drug

02-Sep-2011 - University of Florida researchers have modified a toxic chemical produced by tiny marine microbes and successfully deployed it against laboratory models of colon cancer.Writing in ACS Medicinal Chemistry Letters, UF medicinal chemists describe how they took a generally lethal byproduct of marine ...

Liver transplant offers new option for rare cancer

Early results suggest significant improvements in survival for challenging bile duct cancer

02-Sep-2011 - Robert “Buzz” Gehle thought the itchy rash he was experiencing was a recurrence of an earlier case of shingles. But when his doctor saw he was also jaundiced, he immediately knew there was a problem with Gehle’s liver. Gehle was diagnosed with cholangiocarcinoma – cancer in the bile duct – in ...

Research will speed tracing bacteria behind salmonella outbreaks

02-Sep-2011 - During such mass food-poisoning outbreaks as the recent contamination of ground turkey, speedy identification of the bacteria involved can save lives and reduce illness. New research co-authored by a Cornell food scientist will accelerate the process of identifying strains of salmonella bacteria ...

Doctors' and nurses' hospital uniforms contain dangerous bacteria a majority of time, study shows

01-Sep-2011 - More than 60 percent of hospital nurses’ and doctors’ uniforms tested positive for potentially dangerous bacteria, according to a study published in American Journal of Infection Control, the official publication of APIC - the Association for Professionals in Infection Control and Epidemiology. ...

Scientists identify insect resistance to Bt

Researchers identify how insects resist Bt pesticides in agriculture

01-Sep-2011 - For the first time, researchers have identified how cabbage looper caterpillars in the field develop resistance to the bacterium Bacillus thuringiensis (Bt), which naturally occurs in the soil and on plants and has been developed into the most successful and widely used biological ...

Lead exposure decreases Indian children’s hand-eye coordination

01-Sep-2011 - Young Indian children exposed to lead poisoning scored low on tests that measured hand-eye coordination, a new study found. Researchers conducted the study on children living in Chennai, India, and examined how lead exposure influenced scores on three motor skill tests – copying figures, matching ...

1001 Genome-Project – On the way to a complete catalog of the Arabidopsis genome

Thanks to its flexible genome the plant can adapt to various environmental conditions

30-Aug-2011 - People can develop new technologies and animals may migrate to other regions. However, plants are tied to their location. Nevertheless, they have found ways to ensure their survival. This is the case for the plant Arabidopsis thaliana, which is found throughout the entire northern hemisphere. But ...

Agilent Technologies and Chungnam National University Collaborate to Further Glycomics Research

29-Aug-2011 - Agilent Technologies Inc. and Chungnam National University announced an agreement to develop new applications, methods, technologies and software tools in the field of glycomics, the study of complex sugars. The university aims to identify and develop biomarkers for diseases such as cancer, ...