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24 Current news of Uni Frankfurt am Mainrss
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Climate change is leading to a decrease in soil moisture and an increase in severe droughts in Europe that adversely affect its woodlands. For a long time now, forest conservationists have been thinking very carefully about which trees they should use for reforestation. Researchers from the ...
Researchers develop new protoeomics procedure
When cells are stressed, they initiate a complex and precisely regulated response to prevent permanent damage. One of the immediate reactions to stress signals is a reduction of protein synthesis (translation). Until now, it was difficult to measure such acute cellular changes. As reported in the ...
Sex-specific processes in schizophrenia and bipolar disorder
Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent. These changes affect gene expression, i.e., transcription of genes for the purpose of ...
Biotechnologists develop robust and efficient methods for the production of new peptide drugs
Microorganisms often assemble natural products similar to product assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS), play a key role in this process. Biotechnologists at Goethe University have now succeeded in changing these enzymes so that entirely new natural products, ...
Researchers decode mechanism for diversifying bioactive phenazines
Bacteria produce a cocktail of various bioactive natural products in order to survive in hostile environments with competing (micro)organisms. In the current issue of Nature Chemical Biology, researchers at Goethe University demonstrate that they do so by modifying basic structures, similar to ...
Innovative methods lead to foundation of start-up Vivlion GmbH
CRISPR/Cas enables the targeted deactivation of genes by cutting DNA at pre-determined sites. This is accomplished by providing the Cas enzyme with a genetic zip code. Using an entire library of zip codes, it is then possible to simultaneously probe multiple sites within the genome, for example ...
Seven of the ten most frequent medications contain chiral agents. These are molecules that occur in right- or left-handed forms. During chemical synthesis both forms usually occur in equal parts and have to be separated afterward, because chirality determines the agent’s effect in the body. ...
Researchers decode structure and function of docking domains in the biosynthesis of peptide natural products
Microorganisms often assemble natural products similar to industrial assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS) play a key role in this process. Biotechnologists at Goethe University have now been able to discover how these enzymes interact with each other. This ...
Function and homeostasis of the brain relies on communication between the complex network of cells, which compose this organ. Consequently, development of the different groups of cells in the brain needs to be coordinated in time and space. The group of Amparo Acker-Palmer (Buchmann Institute of ...
Differences in intelligence have so far mostly been attributed to differences in specific brain regions. However, are smart people’s brains also wired differently to those of less intelligent persons? A new study published by researchers from Goethe University Frankfurt (Germany) supports this ...