Incurable liver disease may prove curable

Research has found a drug that can spur liver regeneration in Alagille syndrome: researcher taking Steps to form a start-up company

12-Jan-2023 - Research led by Associate Professor Duc Dong, Ph.D., has shown for the first time that the effects of Alagille syndrome, an incurable genetic disorder that affects the liver, could be reversed with a single drug. The study, published in the Proceedings of the National Academy of Sciences, has the ...

How a protein promotes cancer progression

14-Dec-2017 - Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex (LUBAC), regulating NFκB and other inflammatory molecules, SHARPIN ...

Scientists find key to regenerating blood vessels

27-Nov-2017 - A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The findings, published in Nature Communications, may improve current strategies ...

Drug short-circuits cancer signaling

07-Aug-2017 - Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have published a study shedding new light on how K-80003 (TX803), an anti-cancer agent discovered at the Institute, prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth. Because the PI3K ...

Underlying molecular mechanism of bipolar disorder revealed

10-May-2017 - An international collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) , with major participation from Yokohama School of Medicine, Harvard Medical School, and UC San Diego, has identified the molecular mechanism behind lithium's effectiveness in ...

New research explains why HIV is not cleared by the immune system

15-Apr-2016 - Scientists at the University of North Carolina (UNC) School of Medicine and Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings have important implications for improving HIV ...

'Big Data' used to identify new cancer driver genes

21-Oct-2015 - In a collaborative study led by Sanford Burnham Prebys Medical Discovery Institute (SBP), researchers have combined two publicly available 'omics' databases to create a new catalogue of 'cancer drivers'. Cancer drivers are genes that when altered, are responsible for cancer progression. The ...

Unravelling nerve-cell death in rare children's disease

27-Mar-2014 - A team of scientists, led by Stuart Lipton, M.D., Ph.D., professor and director of the Neuroscience and Aging Research Center at Sanford-Burnham Medical Research Institute (Sanford-Burnham), recently discovered why cerebellar granule cell neurons in patients suffering from ataxia-telangiectasia ...

A cautionary tale on genome-sequencing diagnostics for rare diseases

13-May-2013 - Children born with rare, inherited conditions known as Congenital Disorders of Glycosylation, or CDG, have mutations in one of the many enzymes the body uses to decorate its proteins and cells with sugars. Properly diagnosing a child with CDG and pinpointing the exact sugar gene that's mutated ...

Heart hormone helps shape fat metabolism

Sanford-Burnham study shows that the pathway to losing fat is heavily influenced by a hormone produced in the heart

08-Feb-2012 - It's well known that exercising reduces body weight because it draws on fat stores that muscle can burn as fuel. But a new study at Sanford-Burnham Medical Research Institute (Sanford-Burnham) suggests that the heart also plays a role in breaking down fat. In their study, published in the Journal ...