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Step by step to the end product through enzyme catalysis

Enzymes from microorganisms can produce valuable chemical substances. In a cascade, they can do that even if they need different environmental conditions


The production of the sugar trehalose, which is used as a functional food and an additive in pharmaceutical products or in cosmetics, is a team effort for enzymes: One takes care of the construction of an energy-rich intermediate product (UDP-glucose), from which the second then makes trehalose. ...


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How people manipulate their own memories

When people think back on their own wedding, they tend to turn it into something even more beautiful than it really was


People remember past experiences through the so-called episodic memory system. In the process, they can manipulate their memories on three levels, describe Dr. Roy Dings and Professor Albert Newen from the Institute of Philosophy II at Ruhr-Universität Bochum in a theoretical paper. It has been ...


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No particular risk of infection of Sars-Cov-2 by cash

For fear of contagion, the pandemic is much more cashless payments


How long do Sars coronaviruses remain infectious on banknotes and coins? Is it possible to become infected through contact with cash? This is the question that experts from the European Central Bank, in collaboration with the Department of Medical and Molecular Virology at the Ruhr-Universität ...


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Reverse optogenetic tool developed


Researchers at the Ruhr-Universität Bochum (RUB) have developed a new optogenetic tool, i.e. a protein that can be controlled in the living organism with light. They used an opsin - a protein found in the brain and eyes - from zebrafish and introduced it into the brains of mice. Unlike other ...


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Two tricks for biocatalysis

Plasmas usually have a destructive effect on enzymes - But in this instance, they supply them with a building block for biocatalysis at the push of a button


Enzymes can do a good job as catalysts – they can, for example, synthesise a specific product, but not its mirror image, which has to be laboriously separated in other processes. However, they are sensitive and are sometimes inactivated by the substrate they convert. Using plasma, the team of ...


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How long-known genes continue to surprise researchers


Alternative splicing can lead to the formation of numerous protein variants. For the first time, alternative splicing has now been systematically analysed for the family of glutamate receptors. Proteins are encoded by genes – however, this information is divided into small coding sections, which ...


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What happens in brain cells affected by Alzheimer’s disease?

Studies on tissue from patients and mini-brains made from stem cells shed light on the disease


In addition to plaques that accumulate outside of nerve cells in the brain, Alzheimer’s disease is also characterised by changes inside these cells. Researchers from the Cell Signalling research group at the Chair of Molecular Biochemistry at RUB, headed by Dr. Thorsten Müller, have been studying ...


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Cancer-promoting Ras protein exists in a pair within cells

Findings could open up a new approach for the development of cancer medications


Almost all attempts to use the Ras protein as a point of attack for medications have so far failed. New knowledge concerning its structure is raising hopes of options in the development of medications. Researchers from Bochum and Osnabrück have gained new insights into the structure of the Ras ...


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How injured nerves stop themselves from healing

Researchers have discovered an unexpected effect: It might open up new avenues for developing therapies after brain or spinal cord damage


Damage to nerve fibers in the central nervous system – brain, spinal cord, or optic nerve– often results in lifelong and severe disabilities, such as paraplegia or blindness. Although we are aware of various reasons why nerves fail to regenerate, their treatment has not yet led to any significant ...


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The hidden machinery of a photosynthetic giant revealed

Rresearchers solved the structure of monomeric photosystem I by cryo-electron microscopy


Photosynthesis is the fundament of almost all live on earth, and yet it is not understood down to the last detail. An international research team has now unravelled one of its secrets. The researchers from Ruhr-Universität Bochum (RUB), Osaka University, Japan, and Kafrelsheikh University, Egypt, ...


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