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DNA building blocks regulate inflammation

Shortage of DNA building blocks in the cell releases mitochondrial DNA


Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell. The reasons for the release are not yet known, but some cardiac and neurodegenerative diseases ...


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More than the sum of mutations

165 new cancer genes identified with the help of machine learning


A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers in Berlin combined a wide variety of data, analyzed it with “Artificial Intelligence” and identified numerous cancer genes. This opens up new perspectives for targeted cancer ...


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New app calculates corona infection risk in rooms

Size of aerosol droplets that virus carriers release strongly influences infectivity


The risk of being infected with the corona virus indoors can now be determined more reliably than before using a web app. A team from the Max Planck Institute for Dynamics and Self-Organization in Göttingen and the University Medical Center Göttingen uses a refined statistical method in the web ...


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Speeding up sequence alignment across the tree of life

A sequence search engine for a new era of conservation genomics


A team of researchers from the Max Planck Institutes of Developmental Biology in Tübingen and the Max Planck Computing and Data Facility in Garching develops new search capabilities that will allow to compare the biochemical makeup of different species from across the tree of life. Its ...


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Stimulating the Immune System to Fight Cancer

Scientists find immunoregulatory substances with newly developed test system


Cancer cells have evolved mechanisms to escape the body's immune defense. Agents that prevent immune escape are attractive targets for the development of new cancer therapies. A group of scientists led by Herbert Waldmann and Slava Ziegler at the Max Planck Institute of Molecular Physiology in ...


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New microscopy method resolves fluorescent molecules with resolution at the nanometer scale


Scientists working with Stefan Hell at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the Heidelberg-based MPI for Medical Research have developed another light microscopy method, called MINSTED, which resolves fluorescently labeled details with molecular sharpness. ...


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Salt consumption controls autoimmune disease

In a surprising finding, high salt consumption is found to regulate the blood-brain barrier permeability to suppress autoimmune disease development in mice


Multiple sclerosis (MS) is a chronic inflammatory disease of the nervous system. In this autoimmune disease, the myelin sheath of the nerve cells is attacked by the patient's own immune system. Several animal models are available to study the disease. Researchers at the Max Planck Institute of ...


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Innovative Blood Test Based on Infrared Light

Monitoring health and detect disorders at an early stage


A new study carried out by a team of laser physicists, molecular biologists and physicians based at LMU Munich and the Max Planck Institute for Quantum Optics has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals. The data provide a ...


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Cells talk at each other to specialize different functions

New concept to describe how cells specialize during development


During development, cells must specialize their function in a well defined timeline: formation of different tissues must be coordinated from a pile of cells. The research group led by Aneta Koseska (former Max Planck Institute of Molecular Physiology (MPI), CAESAR Bonn) has now developed a new ...


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Neandertal gene variants and Covid-19

Neandertal gene variants both increase and decrease the risk for severe Covid-19


Last year, researchers atthe Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and at Karolinska Institutet in Sweden showed that a major genetic risk factor for severe Covid-19 is inherited from Neandertals. Now the same researchers show, that Neandertals also contributed ...


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