New mechanism involved in memory loss associated with aging discovered

29-Jun-2018 - A study led by Luísa Lopes, Group Leader at Instituto de Medicina Molecular João Lobo Antunes describes a new mechanism involved in memory loss associated with aging. The work developed over 3 years by a team of Portuguese, French and German scientists now shows that specific changes in the ...

When low batteries are a good thing

27-Jun-2018 - Every day the human gut works on a fine-tuned balance that ensures the retention of essential nutrients while it prevents the entrance of potential armful microbes. Contributing to this surveillance system is a specialised group of immune cells that are held back due to unknown reasons although ...

Could this be malaria's Achilles heel?

08-Nov-2017 - Portuguese researchers at Instituto de Medicina Molecular (iMM) Lisboa have identified a defence mechanism by which the malaria parasite can survive inside its host's liver cells, a crucial stage where the parasite acquires the capacity to infect red blood cells causing the symptoms associated ...

Mechanism involved in novel drug design with potential to treat tuberculosis

16-Oct-2017 - A team of researchers from Instituto de Medicina Molecular (iMM) Lisboa successfully used a pioneer method to chemically modify a protein's components with potential medical applications and an impact in the fight against tuberculosis. To design novel drugs it is essential to understand the ...

IMM, Cenix and Alnylam Discover New Targets in Malaria Infection with RNAi Technology

In Vitro and In Vivo Findings Published in the Journal PLoS Pathogens Identify Novel Host Targets Involved in Malaria Infection

13-Nov-2008 - Alnylam Pharmaceuticals, Inc. and Cenix BioScience GmbH announced the publication of a new study in the journal PLoS Pathogens demonstrating in vitro and in vivo RNAi-mediated silencing of novel host factors involved in malaria infection. The work resulted from an ongoing malaria research ...

Instituto de Medicina Molecular, Cenix BioScience, and Alnylam Pharmaceuticals discover new pathway for malaria infection

New research using RNAi technologies published on the first molecular link between malaria and the host cholesterol uptake pathway

15-Sep-2008 - Cenix BioScience GmbH, Alnylam Pharmaceuticals, Inc. and the Lisbon-based biomedical research centre Instituto de Medicina Molecular (IMM) announced the publication of their collaborative study in Cell Host & Microbe, describing the discovery and in vivo validation of scavenger receptor BI ...

Cenix BioScience and The Instituto de Medicina Molecular Initiate First Genome-Scale RNAi Screen for Novel Malaria Genes

04-Jul-2005 - Cenix BioScience GmbH (Dresden) and the Instituto de Medicina Molecular (IMM, Lisboa) have initiated a research collaboration to identify human genes required for the malaria infection process, using systematic genome-scale RNAi screening. The identified genes will represent excellent candidates ...