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62 Current news of Helmholtz-Zentrum für Infektionsforschungrss
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Researchers succeed in deep sequencing RNA of single bacteria
Bacteria show a wide range of capabilities in withstanding antibiotic treatment or attack by our immune system, which are great challenges in infection research. Scientists at the Würzburg-based Helmholtz Institute for RNA-based Infection Research (HIRI), a site of the Helmholtz Centre for ...
"Many indications suggest that the immune system stands in its own way during severe courses of COVID-19"
Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition. Experts from Charité – Universitätsmedizin Berlin, the University of Bonn, ...
Researchers develop a thermodynamic model to study frameshifting
In the genetic blueprint for proteins, the information for each amino acid is encoded by codons. A codon consists of three consecutive building blocks of messenger RNA (mRNA), a base triplet that encodes exactly one amino acid. During protein synthesis, adaptor molecules - called tRNAs - ...
Modified cancer drug effective against multi-resistant bacteria
Antibiotic-resistant bacteria are increasingly the source of deadly infections. A team of scientists from the Technical University of Munich (TUM) and the Helmholtz Center for Infection Research (HZI) in Braunschweig have now modified an approved cancer drug to develop an active agent against ...
Researcher discovers new selection mechanism for natural formation of broadly neutralising antibodies
New influenza vaccines are required every autumn, because the viruses constantly change the components to which our immune protection responds. Medical research is focusing on universal vaccines that target more stable parts of the viruses. This new generation of broadly neutralising antibodies ...
Researchers give insights into itaconic acid synthesis
For a long time, itaconic acid was only known as a metabolic product of fungi. Its function was unknown, but for decades it has been used industrially for polymer production. In 2013, it was surprisingly discovered as an important metabolic product in the immune system. This newly described role ...
An innovative method identifies newly activated genes within individual cells
Cells are equipped with multiple defense mechanisms to fight off intruders. Genes encode the building blocks of the response that must be activated during an enemy attack in an ordered manner. Scientists at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, one of the ...
Researchers decipher important steps in the formation of a natural antibiotic
In the 1950s, researchers discovered bottromycins – natural substances produced by bacteria with antibiotic activity. Since these substances even kill human pathogens such as the hospital germ MRSA (methicillin-resistant Staphylococcus areus), they are of interest for drug development. After the ...
Medically relevant compounds can often be found in nature. To make them suitable for drugs, they need to be isolated from their natural sources. If sufficient quantities of the agent cannot be isolated in that manner, chemical synthesis comes into play. Without chemical synthesis, many agents ...
Researchers identify target on the viral envelope and develop customised agents
The treatment of hepatitis C has been based on specific effective antiviral medications for a number of years. Since future development of resistance cannot be ruled out, alternative treatment options are being researched as well. So-called cell entry inhibitors are considered to be promising ...