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60 Current news of Helmholtz-Zentrum für Infektionsforschung

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Predicting slippery spots for the ribosome

Researchers develop a thermodynamic model to study frameshifting

18-Dec-2019

In the genetic blueprint for proteins, the information for each amino acid is encoded by codons. A codon consists of three consecutive building blocks of messenger RNA (mRNA), a base triplet that encodes exactly one amino acid. During protein synthesis, adaptor molecules - called tRNAs - ...

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From cancer medication to antibiotic

Modified cancer drug effective against multi-resistant bacteria

18-Dec-2019

Antibiotic-resistant bacteria are increasingly the source of deadly infections. A team of scientists from the Technical University of Munich (TUM) and the Helmholtz Center for Infection Research (HZI) in Braunschweig have now modified an approved cancer drug to develop an active agent against ...

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Super-antibody strategy for universal vaccines

Researcher discovers new selection mechanism for natural formation of broadly neutralising antibodies

31-Oct-2019

New influenza vaccines are required every autumn, because the viruses constantly change the components to which our immune protection responds. Medical research is focusing on universal vaccines that target more stable parts of the viruses. This new generation of broadly neutralising antibodies ...

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How the body produces an endogenous antibiotic with anti-inflammatory effects

Researchers give insights into itaconic acid synthesis

02-Oct-2019

For a long time, itaconic acid was only known as a metabolic product of fungi. Its function was unknown, but for decades it has been used industrially for polymer production. In 2013, it was surprisingly discovered as an important metabolic product in the immune system. This newly described role ...

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Researchers visualize the battle between virus and host cells at the single-cell level

An innovative method identifies newly activated genes within individual cells

12-Jul-2019

Cells are equipped with multiple defense mechanisms to fight off intruders. Genes encode the building blocks of the response that must be activated during an enemy attack in an ordered manner. Scientists at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, one of the ...

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How bacteria produce antibiotics

Researchers decipher important steps in the formation of a natural antibiotic

28-Jun-2019

In the 1950s, researchers discovered bottromycins – natural substances produced by bacteria with antibiotic activity. Since these substances even kill human pathogens such as the hospital germ MRSA (methicillin-resistant Staphylococcus areus), they are of interest for drug development. After the ...

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Inhoffen Medal 2019 awarded to specialist for synthetic organic chemistry

08-Apr-2019

Medically relevant compounds can often be found in nature. To make them suitable for drugs, they need to be isolated from their natural sources. If sufficient quantities of the agent cannot be isolated in that manner, chemical synthesis comes into play. Without chemical synthesis, many agents ...

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Eliminating hepatitis C viruses effectively

Researchers identify target on the viral envelope and develop customised agents

27-Mar-2019

The treatment of hepatitis C has been based on specific effective antiviral medications for a number of years. Since future development of resistance cannot be ruled out, alternative treatment options are being researched as well. So-called cell entry inhibitors are considered to be promising ...

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Evotec and Helmholtz Centre joining platforms and forces for novel antibiotics

21-Feb-2019

Evotec AG and the Helmholtz Centre for Infection Research (“HZI”) announced a collaboration with the goal to address a major global health threat by developing novel antibiotics that overcome drug-resistant bacterial pathogens. Research activities will initially be focused on the optimisation of ...

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How bacteria turn off an antibiotic

19-Dec-2018

Many common antibiotics are increasingly losing their effectiveness against multi-resistant pathogens, which are becoming ever more prevalent. Bacteria use natural means to acquire mechanisms that protect them from harmful substances. For instance against the agent albicidin: Harmful ...

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