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Hematoxylin as a killer of CALR mutant cancer cells

New therapeutic approach for the treatment of primary myelofibrosis

11-Dec-2020

Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Scientists of the research group of Robert Kralovics, Adjunct Principal Investigator at the CeMM Research Center for Molecular ...

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Study of hundreds of proteins in parallel

First highly scalable method developed to monitor protein levels and localizations in cells

20-Nov-2020

CeMM researchers have developed a highly scalable method which allows for the study of hundreds of proteins in parallel in order to monitor the changes of their levels and localization in the cell. This novel strategy is a notable contribution, not only to drug development for future treatments ...

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Allergic immune responses help fight bacterial infections

Exciting discovery could also explain why the body has maintained the “allergy module” throughout evolution

11-Sep-2020

Researchers from CeMM Research Center of Molecular Medicine of the Austrian Academy of Sciences, the Medical University of Vienna and Stanford University School of Medicine, have found that a module of the immune system, which is best known for causing allergic reactions, plays a key role in ...

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Missing component of innate immune signaling identified

Discovery highlights a potential new target for the development of drugs to treat certain autoimmune diseases

18-May-2020

How cells recognize pathogens and alert the immune system swiftly is a fundamental process of high importance for the survival of any species, including humans. A key role is ascribed to so-called adapters, that equal little molecular platforms inside cells where signals from pathogen detectors ...

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Single-cell RNA seq method developed to accurately quantify cell-specific drug effects in pancreatic islets

Findings could open up potential therapeutic avenues to treat Type 1 diabetes

14-May-2020

Researchers from Stefan Kubicek’s and Christoph Bock’s groups, at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, have developed a method to accurately assess the effect of specific drugs in isolated pancreatic tissue by using a refined single-cell ...

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First SARS-CoV-2 genomes in Austria openly available

07-Apr-2020

The first 21 SARS-CoV-2 genomes in Austria have now been completed and published within the scope of the “Mutational Dynamics of SARS-CoV-2” project recently launched by CeMM in close collaboration with the Medical University of Vienna. The project aims at sequencing 1,000 viral genomes obtained ...

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Novel mathematical framework provides a deeper understanding of how drugs interact

15-Nov-2019

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences have developed a new methodology characterizing more precisely how drugs influence each other when combined during treatment. Their analysis of over 30k drug pairs applied to cell lines identified ...

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Novel paradigm in drug development

Understanding resistance mechanisms to targeted protein degradation

26-Aug-2019

Targeted protein degradation (TPD) is a new paradigm in drug discovery that could lead to the development of new medicines to treat diseases such as cancer more effectively. A recent study by researchers at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences reveals ...

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BAFfling cancer growth strategies: new targets for chromatin remodeling mutations identified

21-Aug-2019

More than one-fifth of all human cancers harbor mutations in one of the members of the BAF chromatin remodeling complex. Deep biochemical and epigenomic characterization of a cell line panel comprehensively representing all these mutations enabled researchers at the CeMM Research Center for ...

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Epigenetic study provides new approaches to combination therapies for aggressive cancers

30-May-2019

Epigenetic processes enable cells to respond to changes in their environment by regulating the activity of their genes. One of the proteins that plays a key role in gene activation is BRD4, a well-characterized "epigenetic reader" that binds to acetylated lysine residues on both histone and ...

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