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Novel mathematical framework provides a deeper understanding of how drugs interact

15-Nov-2019

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences have developed a new methodology characterizing more precisely how drugs influence each other when combined during treatment. Their analysis of over 30k drug pairs applied to cell lines identified ...

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Novel paradigm in drug development

Understanding resistance mechanisms to targeted protein degradation

26-Aug-2019

Targeted protein degradation (TPD) is a new paradigm in drug discovery that could lead to the development of new medicines to treat diseases such as cancer more effectively. A recent study by researchers at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences reveals ...

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BAFfling cancer growth strategies: new targets for chromatin remodeling mutations identified

21-Aug-2019

More than one-fifth of all human cancers harbor mutations in one of the members of the BAF chromatin remodeling complex. Deep biochemical and epigenomic characterization of a cell line panel comprehensively representing all these mutations enabled researchers at the CeMM Research Center for ...

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Epigenetic study provides new approaches to combination therapies for aggressive cancers

30-May-2019

Epigenetic processes enable cells to respond to changes in their environment by regulating the activity of their genes. One of the proteins that plays a key role in gene activation is BRD4, a well-characterized "epigenetic reader" that binds to acetylated lysine residues on both histone and ...

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Epigenetic analysis of aggressive brain tumors

30-Aug-2018

Glioblastoma is a brain cancer with devastating prognosis. A new collaborative study by scientists from CeMM, MedUni Vienna and the Austrian Brain Tumor Registry network demonstrates how epigenetic analysis of tumor samples collected in routine clinical practice could be used to better classify ...

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Artificial gene defect reveals target to fight genetic disease

13-Jun-2018

DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react and ...

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How a virus becomes chronic

22-Dec-2017

Chronic viral infections like HIV or hepatitis are among the biggest threads to human health worldwide. While an acute viral infection usually results in a full recovery and effective immune memory, chronic viruses evade the immune system and remain permanently in their host´s body. Treating such ...

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Pharmacoscopy: Next-Generation Microscopy

New possibilities for drug discovery

26-Apr-2017

A novel microscopy method allows unprecedented insights into the spatial organization and direct interactions of immune cells within blood and other liquid multi-lineage tissues. The assay, called “Pharmacoscopy”, developed and patented by scientists from CeMM Research Center for Molecular ...

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Breakthrough in diabetes research

Cells produce insulin instead upon artemisinin treatment

05-Dec-2016

It promises to be a simple and elegant strategy to heal diabetes type 1: Replacing the destroyed beta-cells in the bodies of patients with newly-produced insulin-secreting cells. For years, researchers around the globe tried various approaches with stem- or adult cells in order to induce this ...

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Exhaled diagnosis – what your breath can reveal about your health

07-Mar-2013

Analytical chemists have measured the levels of selected organic compounds found in human breath, with the aim of one day applying the technique to the routine diagnosis of disease. The analysis of biomarkers in exhaled air and in blood can reveal the presence of cancer, the rejection of organs ...

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